Ignite Creation Date:
2024-10-25 @ 8:03 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06572098
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
None
First Post:
2024-08-23
Brief Title:
The Effect of Complex Decongestıve Therapy on Oxıdatıve Stress and Antıoxıdants
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effect of Complex Decongestıve Therapy on Oxıdatıve Stress and Antıoxıdants In Patıents Wıth Lymphedema After Breast Cancer Treatment
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
It is aimed to determine the changes of complex decongestive therapy applications on oxidative stress parameters and antioxidants in patients with lymphedema after breast cancer treatment
Detailed Description:
Lymphedema which is the most common late complication of patients undergoing cancer treatment affects the physical social and psychological lives of the individual and decreases the quality of life as it causes motor dysfunctions cosmetic deformations and psychological disorders The addition of radiotherapy to surgical intervention increases the risk of lymphedema by 36
When free radicals increase in intensity they cause structural defects in lipids proteins and nucleic acids and as a result they are a cause and risk factor for chronic diseases such as cancer neurodegenerative diseases and cardiovascular diseases
Cancer cells produce high levels of reactive oxygen species ROS due to their fast metabolism and impaired cellular signaling mechanisms High levels of ROS are generally harmful to cells and the redox state of cancer cells is different from normal cells Therefore cancer cells maintain ROS levels at a moderately high tumorigenic level above the low cytostatic level but below levels that may be cytotoxic The oxidative stress state in a cancer cell is different from the oxidative stress state in a normal cell It is also well known that increased oxidative stress and inflammation are associated with cancer risk The number of studies investigating the effect of complex decongestive therapy which is stated to be the most effective treatment method in the treatment of lymphedema the most common complication after breast cancer treatment on oxidative stress and antioxidant levels is quite limited
In this study it was aimed to reveal the changes of complex decongestive therapy applications on oxidative stress parameters and antioxidants in participants with lymphedema after breast cancer treatment
When free radicals increase in intensity they cause structural defects in lipids proteins and nucleic acids and as a result they are a cause and risk factor for chronic diseases such as cancer neurodegenerative diseases and cardiovascular diseases
Cancer cells produce high levels of reactive oxygen species ROS due to their fast metabolism and impaired cellular signaling mechanisms High levels of ROS are generally harmful to cells and the redox state of cancer cells is different from normal cells Therefore cancer cells maintain ROS levels at a moderately high tumorigenic level above the low cytostatic level but below levels that may be cytotoxic The oxidative stress state in a cancer cell is different from the oxidative stress state in a normal cell It is also well known that increased oxidative stress and inflammation are associated with cancer risk The number of studies investigating the effect of complex decongestive therapy which is stated to be the most effective treatment method in the treatment of lymphedema the most common complication after breast cancer treatment on oxidative stress and antioxidant levels is quite limited
In this study it was aimed to reveal the changes of complex decongestive therapy applications on oxidative stress parameters and antioxidants in participants with lymphedema after breast cancer treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None