Ignite Creation Date:
2024-10-26 @ 3:34 PM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06502223
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-06-28
Brief Title:
Impact of Gut Microbiota and Tryptophan Metabolites on Acute Pain in Lumbar Disc Herniation Surgery Patients
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Impact of Microbiota and Associated Blood Tryptophan Metabolites on Pain Perception in Patients Undergoing Lumbar Disc Herniation Surgery
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
It is well-established that the gut microbiota plays a crucial role in various pain mechanisms including visceral pain inflammatory pain headache neuropathic pain and opioid tolerance Changes in the gut microbiome can alter pain perception In our study The investigator investigated the effects of microbiota alterations and the associated tryptophan metabolites on acute pain using the Visual Analog Scale VAS
Detailed Description:
The study included patients aged 18 and above undergoing lumbar disc herniation surgery Blood samples were collected preoperatively at 8 hours and at 24 hours postoperatively to analyze tryptophan metabolites picolinic acid 3- Hydroxykynurenine anthranilic acid kynurenine quinolinic acid kynurenic acid xanthurenic acid Concurrent VAS pain assessments were conducted and correlations between tryptophan metabolites and VAS were evaluated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None