Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06502665
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
None
First Post:
2024-07-09
Brief Title:
Second Ovulation Induction
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Outcomes From Secondary Ovulation Induction Following Failed Oocyte Pick-up IVF Cycles
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Studies reported various risk factors for inadequate ovulation induction such as body mass index low ovarian reserve low baseline FSH and LH and previous use of contraception or agonist
The flexibility to use human chorionic gonadotropin hCG or gonadotropin-releasing hormone agonist GnRHa in ovulation induction for antagonist protocol or progestin primed ovarian stimulation PPOS is an advantage helping fertility doctors to decrease the risk of ovarian hyperstimulation syndrome However luteinizing hormone LH levels 15UIL and progesterone 1113nmolL eight to twelve hours post GnRHa trigger were highly correlated to failed oocyte pickup FOP
Rescue hCG have been found to increase favorable outcomes in patients with FOP The presence of false FOP could be due pharmaceutical reasons and human error Genuine FOP could be due to intrinsic ovarian pathology
The FOP is defined as the absence of oocytes after ovarian stimulation and follicular aspiration It is an uncomfortable situation for the patient and medical team to deal with due to the apparent expectations of favorable results
Ovulation induction could be via GnRHa HCG or both in antagonist protocol and PPOS protocol Long or short agonist protocol could be triggered only via HCG
The flexibility to use human chorionic gonadotropin hCG or gonadotropin-releasing hormone agonist GnRHa in ovulation induction for antagonist protocol or progestin primed ovarian stimulation PPOS is an advantage helping fertility doctors to decrease the risk of ovarian hyperstimulation syndrome However luteinizing hormone LH levels 15UIL and progesterone 1113nmolL eight to twelve hours post GnRHa trigger were highly correlated to failed oocyte pickup FOP
Rescue hCG have been found to increase favorable outcomes in patients with FOP The presence of false FOP could be due pharmaceutical reasons and human error Genuine FOP could be due to intrinsic ovarian pathology
The FOP is defined as the absence of oocytes after ovarian stimulation and follicular aspiration It is an uncomfortable situation for the patient and medical team to deal with due to the apparent expectations of favorable results
Ovulation induction could be via GnRHa HCG or both in antagonist protocol and PPOS protocol Long or short agonist protocol could be triggered only via HCG
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None