Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06503510
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-10
Brief Title:
Role of Interleukin-13 Pathways on Pain and Itch Sensitivity
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Role of the Interleukin-13 Pathways on Pain and Itch Sensitivity in Patients With Atopic Dermatitis and Healthy Volunteers
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Atopic dermatitis AD is as chronic inflammatory skin disorder affecting 20 of the worlds population Intense itch and skin pain are the main symptoms Research has shown that the proteins interleukins are involved in inflammation and itch in atopic dermatitis The medicinal product called Lebrikizumab used for treatment of AD has shown to block the interleukin called IL-13 The purpose of this experiment is to evaluate the role of IL-13 in itch in both healthy subjects and people with atopic dermatitis
Detailed Description:
Atopic dermatitis AD is as chronic inflammatory skin disorder affecting 20 of the worlds population Intense itch and skin pain are the main symptoms Research has shown that the interleukin-13 is involved in inflammation and itch in atopic dermatitis by increasing the neuronal sensitivity to pruritogens However the physiological mechanisms by which IL-13 increases the itch sensitivity are unclear The aim of this project is to use for the first time in humans the monoclonal antibody Lebrikizumab that inhibits IL-13 with high affinity as a novel experimental tool to modulate the IL-13 pathway and evaluate its role in the transmission and processing of itch and pain
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None