Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06503757
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-10
Brief Title:
ILD In Obese Patients With OSA
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Misinterpretation of ILD In Obese Patients With OSA
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Assess the impact of obesity and OSA on the interpretation of high-resolution computed tomography HRCT findings in patients with ILD
Identify specific challenges or confounding factors that may contribute to the misinterpretation of HRCT findings in this population
Evaluate the potential consequences of misinterpretation including delayed or inaccurate diagnosis inappropriate treatment decisions and suboptimal patient outcomes
Identify specific challenges or confounding factors that may contribute to the misinterpretation of HRCT findings in this population
Evaluate the potential consequences of misinterpretation including delayed or inaccurate diagnosis inappropriate treatment decisions and suboptimal patient outcomes
Detailed Description:
Obesity and obstructive sleep apnea OSA can lead to radiographic findings on HRCT that may be mistaken for interstitial lung disease ILD The increased adipose tissue deposition and altered lung mechanics associated with obesity as well as the chronic intermittent hypoxia seen in OSA can result in HRCT changes such as ground-glass opacities septal thickening and reduced lung volumes
Several studies have highlighted the potential for misdiagnosis of ILD in obese patients with OSA A retrospective analysis by Washko et al found that 32 of obese individuals with suspected ILD were subsequently reclassified as having changes related to obesity and OSA rather than true interstitial lung disease Similarly a study by Patel et al reported that 27 of patients referred for evaluation of suspected ILD were found to have findings attributable to obesity and OSA rather than an underlying interstitial lung process
The accurate differentiation between ILD and the HRCT changes associated with obesity and OSA is crucial as the management strategies for these conditions differ significantly Misdiagnosis can lead to unnecessary and potentially harmful treatments as well as delayed recognition and management of the underlying obesity and OSA
Therefore a comprehensive clinical evaluation including assessment of body mass index sleep study findings and consideration of the full clinical context is essential to correctly distinguish between ILD and the radiographic changes seen in obese patients with OSA
Several studies have highlighted the potential for misdiagnosis of ILD in obese patients with OSA A retrospective analysis by Washko et al found that 32 of obese individuals with suspected ILD were subsequently reclassified as having changes related to obesity and OSA rather than true interstitial lung disease Similarly a study by Patel et al reported that 27 of patients referred for evaluation of suspected ILD were found to have findings attributable to obesity and OSA rather than an underlying interstitial lung process
The accurate differentiation between ILD and the HRCT changes associated with obesity and OSA is crucial as the management strategies for these conditions differ significantly Misdiagnosis can lead to unnecessary and potentially harmful treatments as well as delayed recognition and management of the underlying obesity and OSA
Therefore a comprehensive clinical evaluation including assessment of body mass index sleep study findings and consideration of the full clinical context is essential to correctly distinguish between ILD and the radiographic changes seen in obese patients with OSA
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None