Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06503887
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-07-11
Brief Title:
COVID-19 and Intestinal Microbiota in Children
Sponsor:
None
Organization:
None
Study Overview
Official Title:
SARS-CoV-2 Intestinal Microbiota and Mucosal Response in Lebanese Children
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
SARS-CoV-2 is the causative agent of the COVID-19 pandemic It appears to cause only mild to moderate upper respiratory symptoms in children in addition to gastrointestinal symptoms resulting from its penetration into intestinal cells Viral respiratory infections are often accompanied by a change in the composition of the gut microbiota GM Additionally intestinal metabolites and integrity appear to be altered This work aims to study the composition of the GM of Lebanese children currently n14 and previously n33 infected with SARS-CoV-2 and to compare it to pre-pandemic controls n39 Furthermore the correlation between the composition of the GM and the intestinal homeostasis are evaluated Clinical data and stool samples were collected from children aged 1 month to 12 years The bacterial profile is determined by quantitative PCR and 16S rRNA sequencing Levels of secretory immunoglobulin A sIgA fecal calprotectin beta defensin type 2 hBD-2 short-chain fatty acids SCFAs tryptophan derivatives and bile acids are also evaluated Given the well-established relationship between the GM and the immune system the results of this study could serve as a potential basis for the implementation of personalized nutrition and biotic supplementations aimed at restoring the host-microbiota symbiosis pointing to the prevention and treatment of COVID-19
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None