Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06504693
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-09
Brief Title:
Iron Status in Children With ADHD
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Iron Status in Children With Attention Deficit Hyperactivity Disorder
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Evaluation of the status of iron deficiency in children with attention deficit hyperactivity disorder
Detailed Description:
Attention-deficithyperactivity disorder ADHD is one of the most prevalent neurodevelopmental disorders affecting 5-8 of children worldwide For about 60 children with ADHD the symptoms persist into adulthood Individuals with ADHD have poorer educational and social outcomes increased injury incidences during daily activities and an elevated risk of developing more severe mental disorders
Attention deficithyperactivity disorder ADHD is a neurodevelopmental disorder defined by persistent impairing and developmentally inappropriate inattentivedisorganized andor hyperactiveimpulsive behaviors that lie at the far end of a normally distributed continuum
Dopamine is one of the key neurotransmitters in the brain Besides its regulatory role in motor and limbic functions dopamine also regulates cognition attention and reward each of which is impaired in ADHD The nigrostriatal dopamine pathway is involved in motor control while the mesolimbic dopamine pathway is involved in motivation and reinforcement learning The mesocortical dopamine pathway originating in the ventral tegmental area VTA and projecting to the prefrontal cortex PFC plays a role in cognitive functioning
Brain iron homeostasis may be important in the pathophysiology of ADHD because iron is a cofactor of the rate-limiting enzyme tyrosine hydroxylase which is required for dopamine synthesis in the metabolism of dopamine and the hypodopaminergic state of the brain in ADHD results in the symptoms of the disorder Moreover iron is colocalized with dopamine in the brain of children with ADHD
In children iron deficiency can therefore lead to delayed cognitive motor attention and memory deficits visual and auditory deficits decreased school performance andor behavioral disorders some with persistent long-term effects
WHO defines anemia in a population as a mild moderate or severe public health problem if its prevalence is 5-20 20-40 or 40 respectively Most of the WHO countries have a moderate-to-severe public health problem with anemia ie over 20 of women and young children are affected In developing countries diets with poor iron bioavailability are the primary cause of iron deficiency anemia
There is a high demand for dietary iron during infancy and preschool years to support physical growth rapid brain development and early learning capacityPrompt identification and treatment of anemia leads to overall improvement of population health outcomes improved physical exercise performance and well-being that results in enhanced economic productivity
Attention deficithyperactivity disorder ADHD is a neurodevelopmental disorder defined by persistent impairing and developmentally inappropriate inattentivedisorganized andor hyperactiveimpulsive behaviors that lie at the far end of a normally distributed continuum
Dopamine is one of the key neurotransmitters in the brain Besides its regulatory role in motor and limbic functions dopamine also regulates cognition attention and reward each of which is impaired in ADHD The nigrostriatal dopamine pathway is involved in motor control while the mesolimbic dopamine pathway is involved in motivation and reinforcement learning The mesocortical dopamine pathway originating in the ventral tegmental area VTA and projecting to the prefrontal cortex PFC plays a role in cognitive functioning
Brain iron homeostasis may be important in the pathophysiology of ADHD because iron is a cofactor of the rate-limiting enzyme tyrosine hydroxylase which is required for dopamine synthesis in the metabolism of dopamine and the hypodopaminergic state of the brain in ADHD results in the symptoms of the disorder Moreover iron is colocalized with dopamine in the brain of children with ADHD
In children iron deficiency can therefore lead to delayed cognitive motor attention and memory deficits visual and auditory deficits decreased school performance andor behavioral disorders some with persistent long-term effects
WHO defines anemia in a population as a mild moderate or severe public health problem if its prevalence is 5-20 20-40 or 40 respectively Most of the WHO countries have a moderate-to-severe public health problem with anemia ie over 20 of women and young children are affected In developing countries diets with poor iron bioavailability are the primary cause of iron deficiency anemia
There is a high demand for dietary iron during infancy and preschool years to support physical growth rapid brain development and early learning capacityPrompt identification and treatment of anemia leads to overall improvement of population health outcomes improved physical exercise performance and well-being that results in enhanced economic productivity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None