Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06504771
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-05
Brief Title:
Clinical and Laboratory Patterns of Pediatric Gross Hematuria
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Clinical and Laboratory Patterns of Pediatric Gross Hematuria in Sohag University Hospital
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Study the demographic clinical laboratory and etiological profile of children with gross hematuria and trace the outcome of these patients for at least 3 months follow up
Detailed Description:
Gross hematuria is a scary but common medical problem in children This condition is considered one of the most important manifestations of kidney and urinary tract diseases When colour of urine with blood is reddish brown or dark or cola coloured the condition is called as macroscopic gross hematuria However blood in urine may not always be visible to the naked eye when it is called as microscopic hematuria
This condition can be transient intermittent or persistent and it may be symptomatic or asymptomatic Hematuria originating from glomerulus is almost never bright red but usually brown tea coloured or cola coloured In contrary hematuria originating from the lower urinary tract is usually pink or red in colour
Pigments and other compounds in certain foods including beets berries and food colourings and drugs sulfonamides rifampicin ibuprofen salicylates phenothiazines metronidazole phenolphthalein chloroquine deferoxamine etc can change the colour of urine that is called false hematuria
The causes of hematuria are very diverse ranging from simple urinary tract infections with rapid recovery to mechanical trauma and severe glomerulonephritis with rapid decline in kidney function it is essential to recognize the underlying disease and treat it accordingly
The causes of gross hematuria may be categorized to whether the hematuria is glomerular or non-glomerular in origin This distinction can be determined by microscopic examination of the urine to detect dysmorphic or monomorphic red blood cells in glomerular and non-glomerular hematuria respectively Although glomerular diseases are nearly always associated with some degree of hematuria gross hematuria as a presenting manifestation is more commonly encountered with acute poststreptococcal glomerulonephritis lupus nephritis and IgA nephropathy Non-glomerular hematuria is most often associated with renal stones tumours idiopathic hypercalciuria bacterial or viral urinary tract infection urolithiasis and structural anomalies of the urinary tract
It is essential to establish the cause and origin of hematuria in each case through proper history clinical features and investigations including laboratory radiological studies andor percutaneous renal biopsy in some cases But at the same time it is important that the pediatrician is aware what any of such procedures might be helpful in establishing a proper diagnosis
This condition can be transient intermittent or persistent and it may be symptomatic or asymptomatic Hematuria originating from glomerulus is almost never bright red but usually brown tea coloured or cola coloured In contrary hematuria originating from the lower urinary tract is usually pink or red in colour
Pigments and other compounds in certain foods including beets berries and food colourings and drugs sulfonamides rifampicin ibuprofen salicylates phenothiazines metronidazole phenolphthalein chloroquine deferoxamine etc can change the colour of urine that is called false hematuria
The causes of hematuria are very diverse ranging from simple urinary tract infections with rapid recovery to mechanical trauma and severe glomerulonephritis with rapid decline in kidney function it is essential to recognize the underlying disease and treat it accordingly
The causes of gross hematuria may be categorized to whether the hematuria is glomerular or non-glomerular in origin This distinction can be determined by microscopic examination of the urine to detect dysmorphic or monomorphic red blood cells in glomerular and non-glomerular hematuria respectively Although glomerular diseases are nearly always associated with some degree of hematuria gross hematuria as a presenting manifestation is more commonly encountered with acute poststreptococcal glomerulonephritis lupus nephritis and IgA nephropathy Non-glomerular hematuria is most often associated with renal stones tumours idiopathic hypercalciuria bacterial or viral urinary tract infection urolithiasis and structural anomalies of the urinary tract
It is essential to establish the cause and origin of hematuria in each case through proper history clinical features and investigations including laboratory radiological studies andor percutaneous renal biopsy in some cases But at the same time it is important that the pediatrician is aware what any of such procedures might be helpful in establishing a proper diagnosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None