Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06507007
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-06-24
Brief Title:
Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids The study focuses on people with Turner syndrome TS
The aim is to find out if there are specific DNA methylation patterns andor RNA expression profiles linked to sensorineural hearing loss SNHL in people with TS Additionally the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile
The main question it aims to answer is Does epigenetics constitute a common denominator for some of the unexplained SNHL cases
Turner Syndrome TS represents an ideal model for studying epigenetics related to sensorineural hearing loss SNHL
Participants will undergo the following tests
Ear examinations
Hearing tests
Balance tests
Blood tests
MRI scans
CBCT cone-beam computed tomography scans
The aim is to find out if there are specific DNA methylation patterns andor RNA expression profiles linked to sensorineural hearing loss SNHL in people with TS Additionally the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile
The main question it aims to answer is Does epigenetics constitute a common denominator for some of the unexplained SNHL cases
Turner Syndrome TS represents an ideal model for studying epigenetics related to sensorineural hearing loss SNHL
Participants will undergo the following tests
Ear examinations
Hearing tests
Balance tests
Blood tests
MRI scans
CBCT cone-beam computed tomography scans
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None