Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06507735
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
None
First Post:
2024-07-11
Brief Title:
The Effects of Mannose Supplementation on Glycosylation and Protein Levels in Human Sera
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effects of Mannose Supplementation on Glycosylation and Protein Levels in Human Sera
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of our study is to investigate the effects of supplemental mannose on sera of humans who are healthy We will perform proteomics studies to elucidate changes to glycan structure and protein level changes We hypothesize that we may find that mannose supplies more properly glycosylated protein substrate and helps expedite protein synthesis that excess mannose leads to alternative glycan structures which confer improved stability or that there are new sites that become glycosylated after mannose supplementation
Detailed Description:
Subjects will be enrolled and a baseline blood sample taken Subjects will take mannose supplements for 1 week 3-4 packets of a standard dose in water then a follow up blood sample will be taken
Subject blood will be analyzed by proteomic analysis for 1 change in glycan structure or 2 other protein based approaches to measure changes in levels of proteins
Subject blood will be analyzed by proteomic analysis for 1 change in glycan structure or 2 other protein based approaches to measure changes in levels of proteins
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None