Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06508242
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-03-25
Brief Title:
Effects Of Vitamin D On Bone Muscle And Adipose Tissue In Obese Subjects
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects Of Vitamin D On Bone Muscle And Adipose Tissue In Obese Subjects A Randomized Double-Blind Placebo-Controlled Study
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DON3
Brief Summary:
Obesity has emerged as a risk factor in the onset of bone muscle and adipose tissue impairments that are further aggravated by vitamin D deficiency A link of an active bone-muscle-adipose axis is represented by Wnt pathway This study will test the hypothesis that vitamin D improves bone muscle and adipose tissue health through a positive modulation of Wnt pathway It will be carried out a double-blind placebo-controlled study of cholecalciferol supplementation in vitamin D-deficient obese adults Specific aims will be 1 to test the direct effect of vitamin D on Wnt signaling in bone muscle and adipose tissue 2 to evaluate muscle mass and strength 3 to assess changes in vitamin D status across different administration strategy weekly fortnightly monthly
This study will provide not only insight of new mechanisms involved in the pathophysiology of obesity-related musculoskeletal impairments but also evidence for new treatment recommendations for vitamin D deficiency in obesity
This study will provide not only insight of new mechanisms involved in the pathophysiology of obesity-related musculoskeletal impairments but also evidence for new treatment recommendations for vitamin D deficiency in obesity
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None