Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06508372
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-08
Brief Title:
Topical Thymoquinone in Psoriasis Vulgaris
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Efficacy and Safety of Thymoquinone Ointment as a Potential New Therapeutic Modality of Psoriasis Vulgaris
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A previous trial found that N sativa oil was more effective as an antipsoriatic agent particularly when taken as both a cream and a pill This confirmed that N sativa possesses antipsoriatic properties and can alleviate psoriasis symptoms
Detailed Description:
Psoriasis is a systemic chronic relapsing immune-mediated disease which often requires a long-term therapy Psoriasis occurs in around 2-3 of the total global population In Egypt the prevalence of psoriasis ranges between 019 and 3
Besides it could have profound implications on the patients psychological state and quality of life
It is presented by erythematous scaly plaques over the preferred sites The pathogenesis of this highly complex disease is still far from being fully understood Keratinocytes hyperproliferation and immune system dysfunctions are well recognized contributors with numerous treatments targeting these unique immunologic dysfunctions
Topical therapy for psoriasis is a current trending subject as it implies good compliance for the patient few adverse systemic reactions and a targeted effect Numerous substances are now being tested from natural to synthetic compounds and already known substances in improved formulas such as vesicular systems
Nigella sativa belongs to the Ranunculaceae family is an annual plant which distributed in southern Europe and some parts of Asia including Syria Turkey Saudi Arabia Pakistan and India Different active pharmaceutical ingredients have been identified in the N sativa seeds including saponins flavonoids cardiac glycosides thymoquinone thymol limonene carvacrol p-cymene alpha-pinene 4-terpineol longifolene t-anethole benzene isoquinoline and pyrazole alkaloids as well as unsaturated fatty acid such as linoleic acid oleic acid and palmitic acid
Thymoquinone is the major bioactive ingredient accounting for 30-48 of the essential oil has high antioxidant and anti-inflammatory immune-boosting cell survival-improving and energy metabolism-promoting properties which may explain why they are so beneficial to our health The anti-inflammatory properties of black seeds and thymoquinone are primarily mediated by COX-2 and PGD2 inhibition
Clinical trials on skin disorders have shown that N sativa essential oil and crude extract are effective Atopic dermatitis Atopic eczemaWart Eczema Acne vulgaris Acute cutaneous leshmaniasis Arsenical keratosis Psoriasis Vitiligo Infant skin infections Acute radiation dermatitis It can be applied as an alternative treatment that helps patients with skin-related problems
Besides it could have profound implications on the patients psychological state and quality of life
It is presented by erythematous scaly plaques over the preferred sites The pathogenesis of this highly complex disease is still far from being fully understood Keratinocytes hyperproliferation and immune system dysfunctions are well recognized contributors with numerous treatments targeting these unique immunologic dysfunctions
Topical therapy for psoriasis is a current trending subject as it implies good compliance for the patient few adverse systemic reactions and a targeted effect Numerous substances are now being tested from natural to synthetic compounds and already known substances in improved formulas such as vesicular systems
Nigella sativa belongs to the Ranunculaceae family is an annual plant which distributed in southern Europe and some parts of Asia including Syria Turkey Saudi Arabia Pakistan and India Different active pharmaceutical ingredients have been identified in the N sativa seeds including saponins flavonoids cardiac glycosides thymoquinone thymol limonene carvacrol p-cymene alpha-pinene 4-terpineol longifolene t-anethole benzene isoquinoline and pyrazole alkaloids as well as unsaturated fatty acid such as linoleic acid oleic acid and palmitic acid
Thymoquinone is the major bioactive ingredient accounting for 30-48 of the essential oil has high antioxidant and anti-inflammatory immune-boosting cell survival-improving and energy metabolism-promoting properties which may explain why they are so beneficial to our health The anti-inflammatory properties of black seeds and thymoquinone are primarily mediated by COX-2 and PGD2 inhibition
Clinical trials on skin disorders have shown that N sativa essential oil and crude extract are effective Atopic dermatitis Atopic eczemaWart Eczema Acne vulgaris Acute cutaneous leshmaniasis Arsenical keratosis Psoriasis Vitiligo Infant skin infections Acute radiation dermatitis It can be applied as an alternative treatment that helps patients with skin-related problems
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None