Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06508671
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-14
Brief Title:
Effects of DL-3-n-butylphthalide on Chemotherapy-Induced Cognitive Impairment
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of DL-3-n-butylphthalide on Chemotherapy-Induced Cognitive Impairment NBP CICIa Prospective Randomized Double Blinded Multicenter Placebo Controlled Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chemotherapy-related cognitive Impairment CICI is a series of neurocognitive deficits experienced during and after cancer chemotherapy Studies have reported that CICI affects 25 to 75 of survivors and can persist for years after chemotherapy is discontinued causing more severe progressive manifestations and placing a heavy burden on families and society Numerous studies have proposed several potential mechanisms and etiologies for CICI including direct neurotoxicity disruption of the blood-brain barrier reduced hippocampal neurogenesis white matter abnormalities secondary neuroinflammatory responses and increased oxidative stress At present there is no clear and effective diagnosis and therapy for CICI and how to diagnose and treat cognitive impairment caused by chemotherapy effectively is still the focus and difficulty
Based on the previous consensus on the application of dl-3-n-butylphthalide butylphthalein can play a neuroprotective role by reducing oxidative stress and inflammatory response inhibiting neuronal apoptosis improving mitochondrial function and other mechanisms and significantly improve the performance of the central nervous system caused by cerebral ischemia and vascular dementia However the increase of neuroinflammatory response and oxidative stress is precisely one of the potential mechanisms of CICI pathogenesis Therefore based on the above findings this study hypothesized that dl-3-n-butylphthalide would also have considerable efficacy in the treatment of CICI
Based on the previous consensus on the application of dl-3-n-butylphthalide butylphthalein can play a neuroprotective role by reducing oxidative stress and inflammatory response inhibiting neuronal apoptosis improving mitochondrial function and other mechanisms and significantly improve the performance of the central nervous system caused by cerebral ischemia and vascular dementia However the increase of neuroinflammatory response and oxidative stress is precisely one of the potential mechanisms of CICI pathogenesis Therefore based on the above findings this study hypothesized that dl-3-n-butylphthalide would also have considerable efficacy in the treatment of CICI
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None