Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06509555
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-13
Brief Title:
Correlation Between Serum TK1 and Pathological Remission of Breast Cancer With Neoadjuvant Chemotherapy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Establishment of Serum TK1 Combined With MRI to Predict Pathological Remission of Breast Cancer With Neoadjuvant Chemotherapy
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The levels and changes of sTK1 among different outcome groups in BCs with different molecular types were compared by stratification to explore whether sTK1 can be used as one of the tumor markers to predict pathological remission of NACT in BC patientsThe changes of serum sTK1 level and ADC before surgery were continuously monitored and combined with other clinicopathological factors the pathological remission prediction model of NACT in BC patients was constructed and verified
Detailed Description:
Female patients diagnosed with breast cancer by breast biopsy and receiving neoadjuvant chemotherapy in our hospital from 2020 to 2024 were selected as the study objects and their puncture pathology data general clinical characteristics hematology test data imaging data and surgical pathology data were collected and the data were collated for statistical analysis The influencing factors of pCR after neoadjuvant therapy were determined by univariate and multivariate logistic regression analysis and the nomogram and ROC curve were drawn The model was verified internally through bootstrap resampling 1000 times and the correction curve was drawn to evaluate the prediction ability of the model
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None