Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06511297
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-09
Brief Title:
Metabolic Control of Aging and Disease - the MetAGE Deep Phenotyping Cohort
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Metabolic Control of Aging and Disease - the MetAGE Deep Phenotyping Cohort Pro-Metage
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Pro-Metage
Brief Summary:
The goal of this prospective observational study is to identify and validate blood based aging biomarkers in relation to cardiometabolic phenotypes of young and old female and male subjects with or without obesity
The main question is to gain insights into the interaction of obesity related metabolic alteration and aging and the relevance of loss of metabolic control in the development of age-related diseases in order to build a foundation for targeted drug- and lifestyle interventions in future studies
The main question is to gain insights into the interaction of obesity related metabolic alteration and aging and the relevance of loss of metabolic control in the development of age-related diseases in order to build a foundation for targeted drug- and lifestyle interventions in future studies
Detailed Description:
The ongoing increase in human life expectancy is steadily reshaping the demographic landscape leading to a higher proportion of older adults many of whom suffer from multiple health conditions These unprecedented demographic shifts come at a significant socioeconomic cost as aging stands as the primary risk factor for chronic disabilities and disorders such as cardiovascular diseases dementia type 2 diabetes obesity steatotic liver disease and infections Consequently promoting healthy aging emerges as one of the most pressing societal challenges in the foreseeable future underscoring the urgent need for clinically validated strategies to extend the disease-free phase of life known as health span
The Pro-MetAGE prospective cohort as part of the clinical program of the MetAGE Cluster of Excellence Austrian Science Fund 1055776COE14 will focus on understanding the metabolic dysregulation associated with aging in a metabolic at-risk population Metabolic control which encompasses various aspects and is influenced by numerous aging indicators might be the primary driver of age-related diseases For instance contemporary markers of biological age such as epigenetic clocks based on DNA methylation and cellular senescence markers correlate more closely with metabolic processes like nutrient sensing and mitochondrial function rather than genome stability or telomere length
Aging entails a gradual deterioration of several fundamental metabolic processes including lipostasis fat metabolism proteostasis protein homeostasis polyamine metabolism and mitochondrial function These intracellular changes are compounded by alterations in intercellular and interorgan communication affecting brain-organ interactions and immune function The decline in these crucial processes can disrupt the regulatory mechanisms of metabolic control in a manner influenced by sex and gender Consequently the loss of metabolic control may exacerbate other aging processes setting off a detrimental cycle of accelerated aging
Disruption in metabolic regulation caused by calorie-rich diets disturbed circadian rhythms or sedentary lifestyle can lead to a diverse set of health issues known collectively as metabolic syndrome These medical conditions including obesity high blood pressure elevated lipid levels insulin resistance and high blood sugar contribute to the development of prevalent age-related diseases such as cardiovascular disease type 2 diabetes retinal degeneration and metabolic dysfunction-associated steatotic liver disease formerly known as nonalcoholic fatty liver disease affecting millions of older individuals globally Additionally there exists a significant link between metabolic imbalance and dysfunction in the immune system resulting in heightened susceptibility to infections diminished response to vaccinations and various neuropsychiatric disorders especially depression Hence understanding the mechanisms underlying metabolic dysregulation holds immense importance in devising preventive measures against some of the most debilitating age-related ailments
The proposed research project aims to prospectively identify and validate aging biomarkers in relation to age- and sex-related cardiometabolic changes in young and old individuals who are lean or obeseoverweight ie a metabolic at-risk population with regard to lipostasis proteostasis polyamine metabolism mitochondrial function inflammation and cellular senescence The goal is to gain insights into the interaction of obesity related metabolic alteration and aging and the relevance of loss of metabolic control in the development of age-related diseases in order to build a foundation for targeted drug- and lifestyle interventions in future studies
The Pro-MetAGE prospective cohort as part of the clinical program of the MetAGE Cluster of Excellence Austrian Science Fund 1055776COE14 will focus on understanding the metabolic dysregulation associated with aging in a metabolic at-risk population Metabolic control which encompasses various aspects and is influenced by numerous aging indicators might be the primary driver of age-related diseases For instance contemporary markers of biological age such as epigenetic clocks based on DNA methylation and cellular senescence markers correlate more closely with metabolic processes like nutrient sensing and mitochondrial function rather than genome stability or telomere length
Aging entails a gradual deterioration of several fundamental metabolic processes including lipostasis fat metabolism proteostasis protein homeostasis polyamine metabolism and mitochondrial function These intracellular changes are compounded by alterations in intercellular and interorgan communication affecting brain-organ interactions and immune function The decline in these crucial processes can disrupt the regulatory mechanisms of metabolic control in a manner influenced by sex and gender Consequently the loss of metabolic control may exacerbate other aging processes setting off a detrimental cycle of accelerated aging
Disruption in metabolic regulation caused by calorie-rich diets disturbed circadian rhythms or sedentary lifestyle can lead to a diverse set of health issues known collectively as metabolic syndrome These medical conditions including obesity high blood pressure elevated lipid levels insulin resistance and high blood sugar contribute to the development of prevalent age-related diseases such as cardiovascular disease type 2 diabetes retinal degeneration and metabolic dysfunction-associated steatotic liver disease formerly known as nonalcoholic fatty liver disease affecting millions of older individuals globally Additionally there exists a significant link between metabolic imbalance and dysfunction in the immune system resulting in heightened susceptibility to infections diminished response to vaccinations and various neuropsychiatric disorders especially depression Hence understanding the mechanisms underlying metabolic dysregulation holds immense importance in devising preventive measures against some of the most debilitating age-related ailments
The proposed research project aims to prospectively identify and validate aging biomarkers in relation to age- and sex-related cardiometabolic changes in young and old individuals who are lean or obeseoverweight ie a metabolic at-risk population with regard to lipostasis proteostasis polyamine metabolism mitochondrial function inflammation and cellular senescence The goal is to gain insights into the interaction of obesity related metabolic alteration and aging and the relevance of loss of metabolic control in the development of age-related diseases in order to build a foundation for targeted drug- and lifestyle interventions in future studies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None