Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06511310
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-06-18
Brief Title:
Exercise Brain Activity and Weight Maintenance
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of Exercise Training on Brain Activity and Its Relation to Weight Maintenance and Appetite Regulation
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to explore how HIIT influences brain function neural and molecular pathways related to weight control setting the stage for future obesity intervention research
Detailed Description:
Participants will include adults aged 18-70 years old with a BMI greater than 19 kgm2 who have undergone bariatric surgery and those who have not Participants who have undergone bariatric surgery must have experienced a clinically significant weight regain defined as over 10 of their maximum weight lost within 1 to 5 years following their bariatric surgery weight regain The study will consist of 3 initial clinical visits for collecting baseline data 12 weeks of high-intensity interval training and three post-training clinical visits At Visit 1 participants will complete anthropometrics and baseline blood draw including an oral glucose tolerance test psychometrics and an MRI safety form Visit 2 will include a DXA scan and metabolic testing including resting metabolic rate and VO2peak testing Visit 3 participants will complete a high-intensity interval training session with two blood draws pre- and post-exercise and two fMRIs pre- and post-exercise Participants will then begin a 12 week high-intensity interval training program completing four weekly 28 minute training sessions at Joslin Diabetes Training Facility and at home The sessions will start with a 3-minute warm-up followed by the main set which includes six rounds of intervals 40 seconds of high intensity and 3 minutes of moderate intensity concluding with a 3-minute cool-down After completing the 12-week high-intensity interval training program subjects will complete clinical visits 4 5 and 6 collecting the same data points as visits 1 2 and 3
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None