Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06515028
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-10
Brief Title:
Effects of Anesthesia Technique on Endothelial Function
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effects of General Anesthesia and Infraclavicular Block Applications on Oxidative Stress and Endothelial Dysfunction in Upper Extremity Surgeries
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study was to compare the effects of two different anesthesia methods general anesthesia and infraclavicular block on oxidative stress and endothelial dysfunction in upper extremity forearm operationsThis prospective study aims to determine the ideal anesthesia method for patients undergoing upper extremity forearm surgeries under tourniquet by comparing general anesthesia and infraclavicular block applications in terms of oxidative stress and ED related to ischemia-reperfusion injury
Detailed Description:
Pneumatic tourniquets are commonly used in orthopedic extremity surgeries to reduce surgical trauma and blood loss When the tourniquet is released it leads to the release of more free oxygen radicals than under physiological conditions resulting in ischemia-reperfusion injury oxidative stress and endothelial dysfunction ED
Endothelial dysfunction is characterized by the imbalance between vasoactive substances such as nitric oxide NO and endothelin which regulate vascular tone by exerting vasodilatory and vasoconstrictive effectsDuring ischemia xanthine oxidase XO derived from xanthine dehydrogenase is the main source of free oxygen radicals FOR including superoxide anion O2- hydrogen peroxide H2O2 and hydroxyl anion OH- Superoxide anion reacts with NO to produce peroxynitrite ONOO- a reactive oxygen derivative Free radicals affect unsaturated fatty acids in membranes leading to the production of malondialdehyde MDA which exerts cytotoxic effects on endothelial cells Increased production of FOR due to oxidative stress and dysfunction of antioxidant mechanisms result in protein carbonylation Protein carbonyl groups PC serve as indicators of severe oxidative damage and loss of protein function
Endothelial dysfunction is characterized by the imbalance between vasoactive substances such as nitric oxide NO and endothelin which regulate vascular tone by exerting vasodilatory and vasoconstrictive effectsDuring ischemia xanthine oxidase XO derived from xanthine dehydrogenase is the main source of free oxygen radicals FOR including superoxide anion O2- hydrogen peroxide H2O2 and hydroxyl anion OH- Superoxide anion reacts with NO to produce peroxynitrite ONOO- a reactive oxygen derivative Free radicals affect unsaturated fatty acids in membranes leading to the production of malondialdehyde MDA which exerts cytotoxic effects on endothelial cells Increased production of FOR due to oxidative stress and dysfunction of antioxidant mechanisms result in protein carbonylation Protein carbonyl groups PC serve as indicators of severe oxidative damage and loss of protein function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None