Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06515431
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-17
Brief Title:
Myocardial Injury After Radical Nephrectomy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Myocardial Injury After Radical Nephrectomy
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MANE
Brief Summary:
Kidney removal for cancer nephrectomy is a major operation People can develop heart complications during or after surgery especially if they are older or already have heart disease One form of heart damage is called myocardial injury MINS This can be detected with a simple and easily available blood test Unlike a heart attack MINS doesnt cause changes in the electrical tracing of the heart ECG and it typically doesnt cause symptoms like pain However it can lead to heart problems and a stroke after surgery We do not know how many people having a nephrectomy develop MINS It is important to know if people are at high risk of MINS to help decide future treatment
There are a few different ways of carrying out nephrectomy surgery These can be traditional open surgery keyhole surgery or robotic surgery We know that MINS is more likely if there has been a lot of bleeding during the operation but other factors are also important Therefore its important to monitor the relationship between blood loss rates of MINS and method of surgery
We aim to recruit 120 participants undergoing nephrectomy to see how many develop MINS and to compare blood loss between different ways of surgery Patients will be asked to consent to have blood tests on the day of and the day after surgery This test will be added to routine hospital blood tests and so no extra samples are needed These results will show how many patients are diagnosed with MINS after nephrectomy Around 90 days after the surgery their quality of life and any further heart or breathing problems will also be recorded
We hope to identify the rates of and risk factors for MINS so future patients can be spared this complication of surgery
There are a few different ways of carrying out nephrectomy surgery These can be traditional open surgery keyhole surgery or robotic surgery We know that MINS is more likely if there has been a lot of bleeding during the operation but other factors are also important Therefore its important to monitor the relationship between blood loss rates of MINS and method of surgery
We aim to recruit 120 participants undergoing nephrectomy to see how many develop MINS and to compare blood loss between different ways of surgery Patients will be asked to consent to have blood tests on the day of and the day after surgery This test will be added to routine hospital blood tests and so no extra samples are needed These results will show how many patients are diagnosed with MINS after nephrectomy Around 90 days after the surgery their quality of life and any further heart or breathing problems will also be recorded
We hope to identify the rates of and risk factors for MINS so future patients can be spared this complication of surgery
Detailed Description:
Patients undergoing nephrectomy have a greater risk of cardiac events requiring admission compared to the general population For example registry data report 21 of patients over 65 undergoing nephrectomy have at least one cardiovascular event after surgery Myocardial injury after non-cardiac surgery MINS is a condition which is associated with increased mortality and a higher rate of major adverse cardiac events MACE in both the immediate perioperative period and within 1-year post-surgery Diagnosis is via the presence of elevated troponin levels in the first 3 days post-surgery in the absence of ischaemic symptoms and ECG changes
The occurrence of MINS following nephrectomy for renal cell carcinoma has not yet been explored Risk factors for MINS include increasing age and post-operative acute kidney injury Results from the British Association of Urological Surgeons BAUS Nephrectomy audit demonstrate that most patients undergoing nephrectomy are over 60 and that increasing age is associated with lower eGFR pre-operatively The accepted further reduction in post-operative GFR with nephrectomy makes these patients at high risk of MINS
The BAUS Nephrectomy audit also demonstrates that elderly patients undergoing nephrectomy are likely to be anaemic preoperatively In at-risk patients any intraoperative haemodynamic instability may progress to myocardial injury and cardiac related complications due to a change in myocardial oxygen demand
Most radical nephrectomies are now performed using robotic or laparoscopic approaches Current evidence from retrospective studies and a small prospective study suggests that there is no difference in perioperative nor oncological outcomes between laparoscopic and robotic radical nephrectomy including blood loss However no studies to date have looked at MINS and large-scale prospective studies comparing the haemodynamic effects of laparoscopic vs robotic nephrectomy are needed
Understanding the spectrum of MINS and its potential impact on patients undergoing nephrectomy is pivotal This could lead to better patient selection and stratified care to improve outcomes Advances in systemic therapy for metastatic disease mean nephrectomy may become more prevalent in persons on multiple therapies As patients undergoing nephrectomy are at high risk of MINS it is vital to have a greater understanding of this potential complication This aligns with the James Lind Alliance Priority Setting Partnership in perioperative care which highlights the importance of research into post-operative complications Furthermore this group also underlines the importance of adequate preoperative discussions with patients which would include the risk of postoperative complications such as MINS
Eligible patients who have consented to the study will have their troponin levels measured on the day of the surgery and at day 1 post-op to diagnose MINS A baseline quality of life assessment will also be made by asking patients to complete an EQ-5D-5L questionnaire Any blood transfusions during the admission period will also be recorded At day 90 post-op the occurrence of MACE events and days out of hospital DAOH90 will be checked and the patient will be contacted to complete the quality-of-life questionnaire again
Baseline assessments
The following demographic information will be prospectively collected by reviewing the patients medical notes
Age sex and ethnicity
Previous history of ischaemic heart disease congestive cardiac failure cerebrovascular disease stroke or TIA diabetes
Tumour characteristics radiological T stage laterality
Pre-op renal function and baseline troponin will be measured on the day of surgery
Primary outcome measure
The primary outcome measure is the proportion of patients undergoing laparoscopic or robotic radical nephrectomy with evidence of myocardial injury MINS This will be defined as a raised troponin level 99th percentile upper reference limit on any sample taken within 72 hours following the operation
Patients will have troponin levels measured on the morning of surgery and at day 1 post-op If applicable this can be retrieved as an add on test on routine samples without the requirement for an additional blood draw to avoid extra burden to patients
Sites will be expected to manage patients post-operatively as per Trust guidelines - this may or may not include troponin monitoring The European Society for Cardiology advocates testing of troponins but does not make treatment recommendations If troponin monitoring is not part of usual care the troponin samples will not be available to the clinical team to avoid any inadvertent additional investigations which may add to patient burden Instead we would arrange the troponin results to be processed after surgery
However the clinical team can request troponin tests for clinical information for example in the assessment of chest pain In this situation the troponin sample would be processed immediately and be available for the clinical team to view The clinical team will be expected to follow local guidelines regarding the clinical management If the clinical team requests a troponin level for clinical assessment we will also note this in the research record
Secondary outcome measures
Perioperative assessments
Any blood transfusions during the intraoperative andor postoperative period will be recorded This will allow assessment of potential cardiovascular instability compared between the groups laparoscopic vs robot-assisted and how this translates to rates of MINS and MACE post-op
90 days - 7 days post-procedure
Patients will be contacted by the research team via telephone to assess the following
The occurrence of any major adverse cardiovascular event myocardial infarction stroke arrhythmia cardiac arrest and cardiac related death during admission will be recorded This will be obtained as part of patient follow up at 90 days post-op
Days out of hospital at 90 days DAOH90 This will be recorded following discussion with the patient and review of local hospital data
Impact on quality of life will be assessed using the EQ-5D-5L via a telephone interview by the research team
The occurrence of MINS following nephrectomy for renal cell carcinoma has not yet been explored Risk factors for MINS include increasing age and post-operative acute kidney injury Results from the British Association of Urological Surgeons BAUS Nephrectomy audit demonstrate that most patients undergoing nephrectomy are over 60 and that increasing age is associated with lower eGFR pre-operatively The accepted further reduction in post-operative GFR with nephrectomy makes these patients at high risk of MINS
The BAUS Nephrectomy audit also demonstrates that elderly patients undergoing nephrectomy are likely to be anaemic preoperatively In at-risk patients any intraoperative haemodynamic instability may progress to myocardial injury and cardiac related complications due to a change in myocardial oxygen demand
Most radical nephrectomies are now performed using robotic or laparoscopic approaches Current evidence from retrospective studies and a small prospective study suggests that there is no difference in perioperative nor oncological outcomes between laparoscopic and robotic radical nephrectomy including blood loss However no studies to date have looked at MINS and large-scale prospective studies comparing the haemodynamic effects of laparoscopic vs robotic nephrectomy are needed
Understanding the spectrum of MINS and its potential impact on patients undergoing nephrectomy is pivotal This could lead to better patient selection and stratified care to improve outcomes Advances in systemic therapy for metastatic disease mean nephrectomy may become more prevalent in persons on multiple therapies As patients undergoing nephrectomy are at high risk of MINS it is vital to have a greater understanding of this potential complication This aligns with the James Lind Alliance Priority Setting Partnership in perioperative care which highlights the importance of research into post-operative complications Furthermore this group also underlines the importance of adequate preoperative discussions with patients which would include the risk of postoperative complications such as MINS
Eligible patients who have consented to the study will have their troponin levels measured on the day of the surgery and at day 1 post-op to diagnose MINS A baseline quality of life assessment will also be made by asking patients to complete an EQ-5D-5L questionnaire Any blood transfusions during the admission period will also be recorded At day 90 post-op the occurrence of MACE events and days out of hospital DAOH90 will be checked and the patient will be contacted to complete the quality-of-life questionnaire again
Baseline assessments
The following demographic information will be prospectively collected by reviewing the patients medical notes
Age sex and ethnicity
Previous history of ischaemic heart disease congestive cardiac failure cerebrovascular disease stroke or TIA diabetes
Tumour characteristics radiological T stage laterality
Pre-op renal function and baseline troponin will be measured on the day of surgery
Primary outcome measure
The primary outcome measure is the proportion of patients undergoing laparoscopic or robotic radical nephrectomy with evidence of myocardial injury MINS This will be defined as a raised troponin level 99th percentile upper reference limit on any sample taken within 72 hours following the operation
Patients will have troponin levels measured on the morning of surgery and at day 1 post-op If applicable this can be retrieved as an add on test on routine samples without the requirement for an additional blood draw to avoid extra burden to patients
Sites will be expected to manage patients post-operatively as per Trust guidelines - this may or may not include troponin monitoring The European Society for Cardiology advocates testing of troponins but does not make treatment recommendations If troponin monitoring is not part of usual care the troponin samples will not be available to the clinical team to avoid any inadvertent additional investigations which may add to patient burden Instead we would arrange the troponin results to be processed after surgery
However the clinical team can request troponin tests for clinical information for example in the assessment of chest pain In this situation the troponin sample would be processed immediately and be available for the clinical team to view The clinical team will be expected to follow local guidelines regarding the clinical management If the clinical team requests a troponin level for clinical assessment we will also note this in the research record
Secondary outcome measures
Perioperative assessments
Any blood transfusions during the intraoperative andor postoperative period will be recorded This will allow assessment of potential cardiovascular instability compared between the groups laparoscopic vs robot-assisted and how this translates to rates of MINS and MACE post-op
90 days - 7 days post-procedure
Patients will be contacted by the research team via telephone to assess the following
The occurrence of any major adverse cardiovascular event myocardial infarction stroke arrhythmia cardiac arrest and cardiac related death during admission will be recorded This will be obtained as part of patient follow up at 90 days post-op
Days out of hospital at 90 days DAOH90 This will be recorded following discussion with the patient and review of local hospital data
Impact on quality of life will be assessed using the EQ-5D-5L via a telephone interview by the research team
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None