Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06516328
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-07-14
Brief Title:
AGEsRAGE Ratio in Diabetic Periodontitis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
AGEsRAGE and IL-17 Levels in Type 2 Diabetic Periodontitis Patients
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to learn about some molecules in the disease mechanism of type 2 diabetes and periodontitis There are end products inside the body called AGEs and their receptors binding to them especially sRAGE RAGE in people with diabetes in hyperglycemic stateThese molecules are important also in periodontitis the disease of teeth that may end with exfoliation of the tooth Diabetes and periodontitis enhance each others disease-causing effects Both is chronic inflammatory diseases and IL-17 is another molecule having role in this process
Totally 64 men and women aged between 27-60 included in the study Study groups were 1participants with healthy teeth and no diabetes 2 participants with periodontitis without diabetes 3participants with periodontitis and controlled diabetes 4participants with periodontitis and uncontrolled diabetes 65 and fasting blood sugar levels 200 mgdl Researchers got saliva and gingival crevicular fluid GCF samples from diseased teeth and examined AGE sRAGE IL-17 levels GCF is a fluid around the crevice of the theeth with different characteristics from saliva
As a result AGEsRAGE ratio and IL-17 levels of diseased groups were higher than healthy group while sRAGE levels were significantly lower in GCF samples Researchers concluded that GCF and saliva AGEsRAGE ratio may represent as a biomarker in periodontitis patients with uncontrolled diabetes
Totally 64 men and women aged between 27-60 included in the study Study groups were 1participants with healthy teeth and no diabetes 2 participants with periodontitis without diabetes 3participants with periodontitis and controlled diabetes 4participants with periodontitis and uncontrolled diabetes 65 and fasting blood sugar levels 200 mgdl Researchers got saliva and gingival crevicular fluid GCF samples from diseased teeth and examined AGE sRAGE IL-17 levels GCF is a fluid around the crevice of the theeth with different characteristics from saliva
As a result AGEsRAGE ratio and IL-17 levels of diseased groups were higher than healthy group while sRAGE levels were significantly lower in GCF samples Researchers concluded that GCF and saliva AGEsRAGE ratio may represent as a biomarker in periodontitis patients with uncontrolled diabetes
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None