Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06518161
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-08
Brief Title:
Development of an Atlas of Respiratory Host-microbiome Interactions in Healthy Volunteers
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Développement dun Atlas Des Interactions hôte-microbiome Respiratoire Chez Des Volontaires Sains
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HEALTHY LUNG
Brief Summary:
The role of the pulmonary microbiome in the pathophysiology of lung disease is becoming increasingly well understood Studies on murine models have highlighted the immunomodulatory and antibacterial activity of certain commensal bacteria such as S mitis and have led to an understanding of their potential therapeutic impact The investigators will therefore couple their analyses of the respiratory microbiome with an in-depth analysis of mucosal immunity In particular they will characterize immune cell types and frequencies using high-dimensional spectral flow cytometry and single cell RNA-sequencing Finally they will study the mediators exchanged between the microbiome and the host using proteomic and metabolomic analyses of respiratory fluids
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None