Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06518278
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-06-13
Brief Title:
Assessing Central Aspects of Pain
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Assessing Central Nervous System Contributions to Accelerate Musculoskeletal Pain Diagnosis and Treatment
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AsCent
Brief Summary:
BACKGROUND Chronic pain continues for more than 12 weeks despite medication or treatment Chronic pain is the main symptom of muscle and joint problems rarely explained by damage to the muscle and joints alone Activity in the central nervous system CNS nerves spinal cord and brain pathways governs our ability to describe pain intensity and our emotional response to pain Musculoskeletal conditions eg inflammatory arthritis osteoarthritis low back pain fibromyalgia share altered CNS pathways acknowledged by recent classifications of primary and nociplastic pain Clinically useful tools to diagnose and measure activity and reveal abnormalities in these CNS pathways are needed to improve clinical decisions and accelerate new treatment development Laboratory pain sensitivity testing and brain imaging confirm the CNS as a primary contributor to pain These assessments are less acceptable or unfeasible for clinical practice Simpler clinical pain sensitivity assessments are being developed The investigators simple Central Aspects of Pain CAP questionnaire detects some people with pain sensitivity and knee rheumatoid arthritis or low back pain Combining the CAP questionnaire reflecting emotional processing and simpler pain sensitivity assessment combining two different dimensions should be better than either approach alone
PURPOSE To optimise diagnosis and measurement of CNS as the primary contribution to chronic musculoskeletal pain by using the CAP questionnaire and simpler pain sensitivity assessments to ensure timely effective diagnosis and treatment
OBJECTIVES 1 Assess the ease ability and performance of the combined CAP questionnaire and simpler pain sensitivity assessments to identify CNS as the primary contributor to chronic pain across musculoskeletal conditions
2 Use the CAP questionnaire alone or with substitute measures of activity in CNS pathways demographic and clinical variables to indicate pain levels at six and twelve weeks
3 Understand the relationship between CAP and simpler pain sensitivity assessment with laboratory pain sensitivity assessments as a tool to inform the current CNS activity contributing to pain
4 Evaluate associations between the CAP questionnaire and simpler pain sensitivity assessments with patient outcomes
PURPOSE To optimise diagnosis and measurement of CNS as the primary contribution to chronic musculoskeletal pain by using the CAP questionnaire and simpler pain sensitivity assessments to ensure timely effective diagnosis and treatment
OBJECTIVES 1 Assess the ease ability and performance of the combined CAP questionnaire and simpler pain sensitivity assessments to identify CNS as the primary contributor to chronic pain across musculoskeletal conditions
2 Use the CAP questionnaire alone or with substitute measures of activity in CNS pathways demographic and clinical variables to indicate pain levels at six and twelve weeks
3 Understand the relationship between CAP and simpler pain sensitivity assessment with laboratory pain sensitivity assessments as a tool to inform the current CNS activity contributing to pain
4 Evaluate associations between the CAP questionnaire and simpler pain sensitivity assessments with patient outcomes
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None