Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06518473
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-14
Brief Title:
Atopy and Frequency of Exacerbation in Chronic Obstructive Pulmonary Disease Patients
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Relation Between Atopy and Frequency of Exacerbation in Chronic Obstructive Pulmonary Disease Patients
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chronic Obstructive Pulmonary Disease COPD is a heterogeneous lung condition characterized by chronic respiratory symptoms dyspnea cough sputum production andor exacerbations due to abnormalities of airways bronchitis bronchiolitis andor alveoli emphysema that cause persistent often progressive airflow obstruction
The presence of non-fully reversible airflow obstruction FEV1FVC 07 post-bronchodilation measured by spirometry confirms the diagnosis of COPD
The presence of non-fully reversible airflow obstruction FEV1FVC 07 post-bronchodilation measured by spirometry confirms the diagnosis of COPD
Detailed Description:
Chronic Obstructive Pulmonary DiseaseCOPD is a heterogeneous lung condition characterized by chronic respiratory symptoms dyspnea cough sputum production andor exacerbations due to abnormalities of airways bronchitis bronchiolitis andor alveoli emphysema that cause persistent often progressive airflow obstruction
The presence of non-fully reversible airflow obstruction FEV1FVC 07 post-bronchodilation measured by spirometry confirms the diagnosis of COPD Inflammation of the bronchial wall is characterized by the presence of neutrophils and macrophages and by increased concentrations of IL-8 and Th1 cytokines as well as by a proteinase antiproteinase imbalance and this could explain the poorer response to inhaled corticosteroids ICs seen in COPD
Asthma may also be a risk factor for the development of chronic airflow obstruction and COPD and Epidemiological Study of Airway Obstructive Disease adults diagnosed of asthma were found to have a 12-fold higher risk of acquiring COPD over time compared to those without asthma after adjusting for smoking
Although both COPD and asthma are associated with chronic inflammation of the respiratory tract there are differences in the inflammatory cells and mediators involved in the two diseases some patients with COPD have an inflammatory pattern with increased eosinophils cells similar to that of asthma
When there is diagnostic of Asthma and COPD overlap ACO uncertainty an elevated total serum immunoglobulin E IgE 100 international unitsmL elevated peripheral blood eosinophil count 300 cellsmicroL and evidence of allergic disease eg skin testing or immunoassays for perennial allergen sensitivity may point a clinician to asthma or Asthma - COPD overlap ACO Elevated sputum eosinophil counts if available are more common in asthma or ACO than COPD The Dutch hypothesis suggests that atopy and bronchial hyper-responsiveness which are important markers of asthma can be involved in the pathogenesis of COPD although there is no clear evidence regarding the frequency of atopy including asthma Allergic rhinitis AR eczema or increased IgE levels in patients with COPD because most studies have involved small samples and limited evaluation of atopy
The presence of non-fully reversible airflow obstruction FEV1FVC 07 post-bronchodilation measured by spirometry confirms the diagnosis of COPD Inflammation of the bronchial wall is characterized by the presence of neutrophils and macrophages and by increased concentrations of IL-8 and Th1 cytokines as well as by a proteinase antiproteinase imbalance and this could explain the poorer response to inhaled corticosteroids ICs seen in COPD
Asthma may also be a risk factor for the development of chronic airflow obstruction and COPD and Epidemiological Study of Airway Obstructive Disease adults diagnosed of asthma were found to have a 12-fold higher risk of acquiring COPD over time compared to those without asthma after adjusting for smoking
Although both COPD and asthma are associated with chronic inflammation of the respiratory tract there are differences in the inflammatory cells and mediators involved in the two diseases some patients with COPD have an inflammatory pattern with increased eosinophils cells similar to that of asthma
When there is diagnostic of Asthma and COPD overlap ACO uncertainty an elevated total serum immunoglobulin E IgE 100 international unitsmL elevated peripheral blood eosinophil count 300 cellsmicroL and evidence of allergic disease eg skin testing or immunoassays for perennial allergen sensitivity may point a clinician to asthma or Asthma - COPD overlap ACO Elevated sputum eosinophil counts if available are more common in asthma or ACO than COPD The Dutch hypothesis suggests that atopy and bronchial hyper-responsiveness which are important markers of asthma can be involved in the pathogenesis of COPD although there is no clear evidence regarding the frequency of atopy including asthma Allergic rhinitis AR eczema or increased IgE levels in patients with COPD because most studies have involved small samples and limited evaluation of atopy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None