Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06527313
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-25
Brief Title:
Investigation of the Effect of Movement Mobilization Concept on Sensory Pain Muscle Activation in Patients With Knee Osteoarthritis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Investigation of the Effect of Movement Mobilization Concept on Quantitative Sensory Parameters Pain Muscle Activation Levels in Patients With Knee Osteoarthritis
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Individuals with knee osteoarthritis are one of the groups most affected by musculoskeletal disorders and experience pain and mobility limitations that significantly limit their daily living activities Quantitative sensory assessment in individuals with osteoarthritis plays a critical role in evaluating disease progression and treatment effectiveness by objectively measuring changes in sensory perception such as proprioception and nociception These changes in sensory perception can negatively affect individuals movement control and balance In this context evaluation of quantitative sensory parameters allows the development of more targeted and effective interventions in the rehabilitation processes of individuals with osteoarthritis
Additionally electromyographic evaluation in individuals with osteoarthritis analyzes muscle activation levels providing a better understanding of the impairments in muscle functions of these individuals EMG data helps to design rehabilitation programs individually by determining to what degree muscles are activated and which muscle groups are more affected Decreased muscle activation or abnormal muscle activation in individuals with osteoarthritis can negatively affect joint stability and mobility Therefore EMG evaluations are an objective method to evaluate the effectiveness of treatment strategies aimed at restoration of muscle functions in individuals with osteoarthritis
The quantitative sensory and EMG evaluations performed in this project aim to improve the quality of life of individuals by offering innovative approaches in the clinical management of individuals with osteoarthritis Therefore these evaluations are of critical importance for the original value and scientific contribution of our project For these reasons the selection of individuals with osteoarthritis and the detailed evaluations made on these individuals and its connection with the methods can be considered as the innovative and original aspect of our project
The aim of this study is to investigate the effect of the Mulligan movement mobilization concept on quantitative sensory parameters pain and muscle activation levels in patients with knee osteoarthritis
Additionally electromyographic evaluation in individuals with osteoarthritis analyzes muscle activation levels providing a better understanding of the impairments in muscle functions of these individuals EMG data helps to design rehabilitation programs individually by determining to what degree muscles are activated and which muscle groups are more affected Decreased muscle activation or abnormal muscle activation in individuals with osteoarthritis can negatively affect joint stability and mobility Therefore EMG evaluations are an objective method to evaluate the effectiveness of treatment strategies aimed at restoration of muscle functions in individuals with osteoarthritis
The quantitative sensory and EMG evaluations performed in this project aim to improve the quality of life of individuals by offering innovative approaches in the clinical management of individuals with osteoarthritis Therefore these evaluations are of critical importance for the original value and scientific contribution of our project For these reasons the selection of individuals with osteoarthritis and the detailed evaluations made on these individuals and its connection with the methods can be considered as the innovative and original aspect of our project
The aim of this study is to investigate the effect of the Mulligan movement mobilization concept on quantitative sensory parameters pain and muscle activation levels in patients with knee osteoarthritis
Detailed Description:
Osteoarthritis is a degenerative disease that occurs especially in weight-bearing joints characterized by a decrease in joint space due to progressive cartilage loss subchondral sclerosis and osteophyte formations Martel et al 2016 Although OA is also seen in the hip spine and hand joints it is most commonly seen in the knee joint Neogi et al 2012 Although the primary change in knee OA is in the articular cartilage of the knee all tissues in and around the joint are affected by OA The clinical features of the condition are pain joint stiffness edema local tenderness in the joint crepitation and swelling muscle weaknesses osteophytes instability subluxations joint deformities limitation of joint movement and functional limitations Sharma 2021
Pain in knee osteoarthritis is a multifactorial phenomenon in which structural neurophysiological and psychosocial factors play a role Emmert et al 2018 Regarding neurophysiological factors it has been shown that there are inflammatory mediators within the articular cartilage that alter afferent sensory inputs and cause plastic changes in the nervous system leading to central sensitization Schaible et al 2022 Although it is such a multifactorial symptom the methods used in the evaluation of pain sensation for osteoarthritis are mostly subjective and include the patients feedback such as visual analog scale numerical rating scale Western Ontario and McMaster Universities Osteoarthritis Index WOMAC and Knee Injury and Osteoarthritis Outcome Score KOOS is limited to tests surveys or scales Dainese et al 2022 Although these scales are an important part of clinical practice and reflect the patients capacity to express his or her own experience they provide subjective information on issues such as the patients pain intensity the effects of pain and its effects on quality of life Dainese et al 2022
Quantitative sensory testing QST is a systematic psychophysical testing method used to measure sensory thresholds for pain touch vibration and temperature sensations Mücke et al 2021 It measures individual sensory perceptions using direct patient feedback It tests sensory loss hypoesthesia hypoalgesia and sensory gain hyperesthesia hyperalgesia allodynia and is used to test the nociceptive and non-nociceptive properties of different afferent nerve fibers and central pathways Mücke et al 2021 Quantitative sensory testing may offer a more objective approach to identifying underlying causes of pain Physical measurements such as nerve damage loss of sensation and changes in touch sensitivity can provide more objective data in assessing pain Arant et al 2021
It has been reported that pain movement limitations and muscle weakness in individuals with osteoarthritis cause indirect effects on muscle activity and functions Petterson et al 2023 Changes in muscle activity usually occur in response to pain or as the patient tries to compensate for functional limitations in the joint Petterson et al 2023
It has been shown that due to pain and movement limitations in the affected joint it causes the individual to change body position and use other muscle groups more Sharma 2021 Avoidance of using the affected joint has also been reported as a factor in the weakening of the relevant muscle groups OA can affect joint stability which can impair muscle coordination Sharma 2021 Superficial Electromyography EMG appears as a method that helps us monitor changes in the activation patterns of certain muscle groups and understand the underlying causes of these functional limitations Simonsen et al 2014
OA treatment generally focuses on relieving symptoms controlling pain improving joint function and improving quality of life Block et al 2020 Treatment methods used in the rehabilitation of patients with OA include exercise electrotherapy and manual therapy Mulligan Movement Mobilization MWM which is among manual therapy practices is a manual therapy concept developed by Brian Mulligan This concept includes a set of techniques aimed at correcting pain and limitations in joint range of motion Anwer et al 2018 It has been supported by studies that in conditions such as osteoarthritis these mobilization techniques can help increase joint mobility and relieve the patients symptoms Alkhawajah et al 2019
The basic principles of Mulligan Movement Mobilization include collaboration with the patient pain-free mobilization and a manual force applied during a specific joint movement It is aimed to increase joint range of motion pain control and functional recovery and to contribute to the patient being more effective in daily activities by increasing joint function Oskay et al 2015 Alkhawajah et al 2019
Pain in knee osteoarthritis is a multifactorial phenomenon in which structural neurophysiological and psychosocial factors play a role Emmert et al 2018 Regarding neurophysiological factors it has been shown that there are inflammatory mediators within the articular cartilage that alter afferent sensory inputs and cause plastic changes in the nervous system leading to central sensitization Schaible et al 2022 Although it is such a multifactorial symptom the methods used in the evaluation of pain sensation for osteoarthritis are mostly subjective and include the patients feedback such as visual analog scale numerical rating scale Western Ontario and McMaster Universities Osteoarthritis Index WOMAC and Knee Injury and Osteoarthritis Outcome Score KOOS is limited to tests surveys or scales Dainese et al 2022 Although these scales are an important part of clinical practice and reflect the patients capacity to express his or her own experience they provide subjective information on issues such as the patients pain intensity the effects of pain and its effects on quality of life Dainese et al 2022
Quantitative sensory testing QST is a systematic psychophysical testing method used to measure sensory thresholds for pain touch vibration and temperature sensations Mücke et al 2021 It measures individual sensory perceptions using direct patient feedback It tests sensory loss hypoesthesia hypoalgesia and sensory gain hyperesthesia hyperalgesia allodynia and is used to test the nociceptive and non-nociceptive properties of different afferent nerve fibers and central pathways Mücke et al 2021 Quantitative sensory testing may offer a more objective approach to identifying underlying causes of pain Physical measurements such as nerve damage loss of sensation and changes in touch sensitivity can provide more objective data in assessing pain Arant et al 2021
It has been reported that pain movement limitations and muscle weakness in individuals with osteoarthritis cause indirect effects on muscle activity and functions Petterson et al 2023 Changes in muscle activity usually occur in response to pain or as the patient tries to compensate for functional limitations in the joint Petterson et al 2023
It has been shown that due to pain and movement limitations in the affected joint it causes the individual to change body position and use other muscle groups more Sharma 2021 Avoidance of using the affected joint has also been reported as a factor in the weakening of the relevant muscle groups OA can affect joint stability which can impair muscle coordination Sharma 2021 Superficial Electromyography EMG appears as a method that helps us monitor changes in the activation patterns of certain muscle groups and understand the underlying causes of these functional limitations Simonsen et al 2014
OA treatment generally focuses on relieving symptoms controlling pain improving joint function and improving quality of life Block et al 2020 Treatment methods used in the rehabilitation of patients with OA include exercise electrotherapy and manual therapy Mulligan Movement Mobilization MWM which is among manual therapy practices is a manual therapy concept developed by Brian Mulligan This concept includes a set of techniques aimed at correcting pain and limitations in joint range of motion Anwer et al 2018 It has been supported by studies that in conditions such as osteoarthritis these mobilization techniques can help increase joint mobility and relieve the patients symptoms Alkhawajah et al 2019
The basic principles of Mulligan Movement Mobilization include collaboration with the patient pain-free mobilization and a manual force applied during a specific joint movement It is aimed to increase joint range of motion pain control and functional recovery and to contribute to the patient being more effective in daily activities by increasing joint function Oskay et al 2015 Alkhawajah et al 2019
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None