Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06527859
Status:
TERMINATED
Last Update Posted:
None
First Post:
2024-07-14
Brief Title:
Correlation Between Levothyroxine and Blood Th17Treg in Pregnant Women With Normal-high TSH and Positive TPOAb
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Correlation Between Different Doses of Levothyroxine Supplementation and Peripheral Blood Th17Treg Balance in Pregnant Women With Normal-high TSH and Positive TPOAb in the First Half of Pregnancy
Status:
TERMINATED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
The study was terminated due to insufficient funding rendering it impossible to continue purchasing reagents for experiments
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this clinical trial is to understand the impact of different doses of levothyroxine on the immune inflammatory response in pregnant women with normal-high TSH and positive TPOAb in the first half of pregnancy It aims to answer the main questions
Are there differences in immune inflammation between normal pregnant women and those in the disease group Can different doses of levothyroxine improve the Th17Treg ratio and cytokine levels in the disease group Researchers first compared the differences between normal pregnant women and those in the disease group and then administered two different doses of levothyroxine to the disease group to observe whether different doses of levothyroxine can improve the immune inflammation in this group
pregnant women in the disease group will Take the same dose of levothyroxine 2550ug every day Return for a follow-up visit after 4 weeks of medication
Are there differences in immune inflammation between normal pregnant women and those in the disease group Can different doses of levothyroxine improve the Th17Treg ratio and cytokine levels in the disease group Researchers first compared the differences between normal pregnant women and those in the disease group and then administered two different doses of levothyroxine to the disease group to observe whether different doses of levothyroxine can improve the immune inflammation in this group
pregnant women in the disease group will Take the same dose of levothyroxine 2550ug every day Return for a follow-up visit after 4 weeks of medication
Detailed Description:
To explore the correlation between different doses of levothyroxine LT4 supplementation and Th17Treg and cytokines in pregnant women with normal-high thyroid stimulating hormone TSH and positive thyroid peroxidase antibody TPOAb in the first half of pregnancy From June 2022 to October 2023 34 pregnant women with high- normal TSH and positive TPOAb in our hospital were selected disease group and 30 healthy pregnant women control group were matched the disease group was divided into HA group and HB group according to the administration of 25 ug LT4 and 50 ug LT4 Blood samples were collected from the control group and the disease group before and 4-8 weeks after intervention to detect thyroid function cytokine and blood lipid levels flow cytometry to determine the proportion of Th17 and Treg cells and methane hydrogen blowing examination was performed in parallel the serological differences between the groups and before and after intervention were compared and correlation analysis was used to analyze thyroid function blood lipids cytokines and Th17Treg
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None