Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06532071
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-29
Brief Title:
Advanced Imaging for Pulmonary Fibrosis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Advanced Imaging for Pulmonary Fibrosis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine if measurements of active collagen deposition using 68GaCBP8 positron emission tomography PET and tissue injury using dynamic contrast-enhanced magnetic resonance imaging DCE-MRI can predict an individual patients pace of disease progression in non-idiopathic pulmonary fibrosis interstitial lung disease non-IPF ILD and identify which individuals will develop progressive pulmonary fibrosis
Detailed Description:
We will recruit 60 participants with non-idiopathic pulmonary fibrosis interstitial lung disease non-IPF ILD on stable dose immunosuppression treatment to be enrolled Participants will undergo combined 68GaCBP8 positron emission tomography PET and dynamic contrast-enhanced magnetic resonance imaging DCE-MRI at baseline We will compare the ability of PET and MRI measurements performed over the whole lung and within regions of interest to identify participants who subsequently develop progressive pulmonary fibrosis as determined by changes in pulmonary function testing quantitative fibrosis on high-resolution computed tomography and respiratory symptoms over 24 months We will also test whether combining the PET and MRI measurements results in more accurate prediction of progression than either modality alone
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None