Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06536452
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-31
Brief Title:
Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Hematopoiesis in Monoclonal B Cell Lymphocytosis MBL and B-Chronic Lymphocytic Leukemia CLL Versus Healthy Age-Matched Control Subjects
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study evaluates hematopoiesis to determine how MBLCLL affected bone marrow responds to fight off infections in the body
Detailed Description:
PRIMARY OBJECTIVES
I Determine the cellular and mechanistic basis of bone marrow BM hematopoietic dysfunction in untreated MBL and CLL patients
II Determine if MBL and CLL B cell derived cellular products directly alter the differentiation and functional capacities of Hematopoietic Stem and Progenitor Cells HSPCs
III Utilize the Emu-Tcl1 transgenic mouse model to determine how MBL and CLL patient-derived cellular products alter BM hematopoiesis
OUTLINE This is an observational study
Patients undergo blood sample collection and bone marrow aspiration and biopsy and have their medical records reviewed on study
I Determine the cellular and mechanistic basis of bone marrow BM hematopoietic dysfunction in untreated MBL and CLL patients
II Determine if MBL and CLL B cell derived cellular products directly alter the differentiation and functional capacities of Hematopoietic Stem and Progenitor Cells HSPCs
III Utilize the Emu-Tcl1 transgenic mouse model to determine how MBL and CLL patient-derived cellular products alter BM hematopoiesis
OUTLINE This is an observational study
Patients undergo blood sample collection and bone marrow aspiration and biopsy and have their medical records reviewed on study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None