Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06536881
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-31
Brief Title:
Gut Microbiome Adverse Effects and Markers Through MEtabolic Reprogramming
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Gut Microbiome Adverse Effects and Markers Through MEtabolic Reprogramming GAMMER Study in Early Stage Breast Cancer Receiving Chemotherapy
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GAMMER
Brief Summary:
This research is being done to test the feasibility of 24-48 hours of water-only fasting to improve delivery of 4 cycles of chemotherapy in those receiving breast cancer treatment either before or after surgery
Detailed Description:
Breast cancer is the most common cancer diagnosed among women worldwide Many women diagnosed with early stage breast cancer ESBC will receive systemic therapy consisting of cytotoxic chemotherapy As therapy-related toxicities are the most common reason for non-completion or dose reduction of chemotherapy new strategies are needed to mitigate adverse effects Preclinical studies show that fasting can prevent toxic effects of oxidative stress and chemotherapy without causing chronic weight loss via modulation of key oncogenic pathways A few studies in women with breast cancer have demonstrated that fasting around chemotherapy is safe and has the same or fewer expected toxicities although the underlying biological mechanisms for these findings is unknown A better understanding of the mechanistic underpinnings of fasting interventions can lead to future interventions to enhance tolerability of chemotherapy and ultimately maintaining intended chemotherapy dosing and schedule
The primary objective of this study is to determine the feasibility of water-only fasting during chemotherapy standard of care Taxotere and Cyclophosphamide TC every 3 weeks for 4 cycles or dose dense doxorubicin and cyclophosphamide ddAC every 2 weeks for 4 cycles in 30 patients with early stage breast cancer Concomitant human epidermal growth factor 2 HER2 therapy is allowed The investigators designed a bed-to-bench feasibility study called the Gut microbiome Adverse effects and Markers through MEtabolic Reprogramming GAMMER study Feasibility will be evaluated by the proportion of participants with self-reported adherence to the fasting regimen The investigators will consider the fasting intervention to be feasible if there is evidence that at least 70 of patients corresponding with 24 out of 30 patients adhere to the intervention for at least 3 of 4 cycles of chemotherapy
Prior to chemotherapy patients will undergo a dose finding for fasting A minimum of one successful 24 hour fast is required during this A maximum of three trials is allowed Participants have the option to progressively increase the fasting window by 12 hours each week as tolerated or to a maximum of 48 hours Patients who are unable to adhere to at least a 24 hour fast during the dose finding phase will be replaced Once patients have a fasting dose established this will be the starting dose used for Cycle 1 of 4 of scheduled chemotherapy
The investigators also aim to understand the impact of short-term fasting on quality of life as well as key cytokines metabolites and gut microbiome Participants will complete patient reported outcomes PROs weekly The investigators will collect fasting labs and research blood with each cycle of chemotherapy 4 instances The investigators will also collect research bloods at baseline The investigators will collect stool samples at baseline and after fasting interventions for Cycle 1 and 3
Through the proposed investigations the investigators will test the feasibility of a promising strategy to augment delivery of chemotherapy in a population at risk for toxicity for cancer therapy and explore the mechanisms by which it may function The long-term goals are to enhance patient experience during chemotherapy improve survival outcomes and reduce disparities in survival between those who received recommended dose of chemotherapy versus those who require a dose reduction due to side effects The study can potentially move the field forward by a identifying key cytokine microbiome and metabolome changes associated with short-term fasting in ESBC and b improving survival outcomes in patients with ESBC
The primary objective of this study is to determine the feasibility of water-only fasting during chemotherapy standard of care Taxotere and Cyclophosphamide TC every 3 weeks for 4 cycles or dose dense doxorubicin and cyclophosphamide ddAC every 2 weeks for 4 cycles in 30 patients with early stage breast cancer Concomitant human epidermal growth factor 2 HER2 therapy is allowed The investigators designed a bed-to-bench feasibility study called the Gut microbiome Adverse effects and Markers through MEtabolic Reprogramming GAMMER study Feasibility will be evaluated by the proportion of participants with self-reported adherence to the fasting regimen The investigators will consider the fasting intervention to be feasible if there is evidence that at least 70 of patients corresponding with 24 out of 30 patients adhere to the intervention for at least 3 of 4 cycles of chemotherapy
Prior to chemotherapy patients will undergo a dose finding for fasting A minimum of one successful 24 hour fast is required during this A maximum of three trials is allowed Participants have the option to progressively increase the fasting window by 12 hours each week as tolerated or to a maximum of 48 hours Patients who are unable to adhere to at least a 24 hour fast during the dose finding phase will be replaced Once patients have a fasting dose established this will be the starting dose used for Cycle 1 of 4 of scheduled chemotherapy
The investigators also aim to understand the impact of short-term fasting on quality of life as well as key cytokines metabolites and gut microbiome Participants will complete patient reported outcomes PROs weekly The investigators will collect fasting labs and research blood with each cycle of chemotherapy 4 instances The investigators will also collect research bloods at baseline The investigators will collect stool samples at baseline and after fasting interventions for Cycle 1 and 3
Through the proposed investigations the investigators will test the feasibility of a promising strategy to augment delivery of chemotherapy in a population at risk for toxicity for cancer therapy and explore the mechanisms by which it may function The long-term goals are to enhance patient experience during chemotherapy improve survival outcomes and reduce disparities in survival between those who received recommended dose of chemotherapy versus those who require a dose reduction due to side effects The study can potentially move the field forward by a identifying key cytokine microbiome and metabolome changes associated with short-term fasting in ESBC and b improving survival outcomes in patients with ESBC
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None