Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06539260
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-01
Brief Title:
Clinical Relationship Between Vitamin D-mediated Th17 and Treg Cells and Parkinsons Disease
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Clinical Relationship Between Vitamin D-mediated Th17 and Treg Cells and Parkinsons Disease
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to detect the expression levels of vitamin D Treg and Th17 in the peripheral blood of patients with Parkinsonamp39s disease PD investigate the impact of TregTh17 imbalance on PD patients and explore the effects of vitamin D intervention on TregTh17 imbalance and clinical outcomes Furthermore this study aims to delve into the potential mechanisms of vitamin D deficiency and TregTh17 imbalance in the pathogenesis of Parkinsonamp39s disease ultimately providing new theoretical evidence for the research prevention and treatment of PD
Detailed Description:
FromJanuary 2023 to July 2024 50 PD patients and 50 health control groups were collected All subjects were from the Parkinson39s outpatient clinic and ward of the Department of Neurology Suzhou Hospital Affiliated to Anhui Medical University This study was approved by the Medical Ethics Committee of Suzhou Municipal Hospital and signed an informed consent form The gender age identity registration place of origin marital status education level occupation smoking drinking occupational exposure body mass index home address and contact information of the patients were collected for detailed registration Current medical history past history family history medication use physical examination previous relevant auxiliary examination results etc Evaluation scales H-Y Staging Scale UPDRS Scale Breg Balance Scale MMSE Intelligence Scale MoCA Scale SDS Depression Self-Rating Scale SAS Anxiety Self-Rating Scale PDSS Parkinson39s Disease Sleep Scale Peripheral blood of patients and control groups were sampled to determine the levels of vitamin D Treg and Th17 PD patients were divided into vitamin D deficiency group and vitamin D non-deficiency group according to the detection of vitamin D Vitamin D deficiency group was randomly divided into intervention group and non-intervention group The intervention group was supplemented with vitamin D and the non-intervention group was not treated The above scale and peripheral blood vitamin D Treg and Th17 levels were evaluated after 3 months of follow-up and compared with the pre-intervention and non-intervention groups Statistical analysis was carried out using SPSS260 and GraphPad Prism v9
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None