Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06543199
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-04
Brief Title:
Evaluation of the Effect of Hypericum Perforatum L and Hyaluronic Acid on Excisional Palatal Wound Healing
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Evaluation of the Effect of Hypericum Perforatum L and Hyaluronic Acid on Excisional
Status:
COMPLETED
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The free gingival graft FGG procedure is one of the surgical approaches used to create a large area of adherent gingiva around the tooth and implant As part of this procedure one SDG at a time is harvested from the donor site of the secondary healing palate The most common postoperative complications are pain burning sensation and delayed wound healing at the donor site Many agents have been used for years to reduce these complications but so far none has been emphasized as the ideal agent In this thesis methods to improve the healing of the hard palate the donor site for SDG surgery and postoperative patient comfort will be compared
Detailed Description:
The free gingival graft FGG procedure is one of the surgical approaches used to create a large adherent gingival and keratinized zone around teeth and implants As part of this procedure SDG is harvested from the palatal donor area The most common postoperative complications from the palatal donor area left to secondary healing are pain burning sensation and delayed wound healing at the donor site Various hemostatic agents dressing materials platelet-rich fibrin and analgesics have been used for years to reduce postoperative complications promote wound healing and increase patient comfort However none of them has been emphasized as the ideal agent in the relevant literature In this thesis we will compare the methods that will improve the healing of the hard palate which is the donor site for SDG surgery and postoperative patient comfort Hypericum perforatum L and hyaluronic acid will be compared by local application to the palatal rotator area
It is aimed to investigate the postoperative effects of topical application of Hypericum perforatum L and hyaluronic acid trade names HYPERICUM PERFORATUM L Dr Özberk St Johns wort oil hyaluronic acid Gengigel Forte Gel on the healing of surgical wounds created in the palatal donor area after SDG and its effects on wound healing Hyaluronic acid is a non-sulfated polysaccharide component of the glycosaminoglycan family which is also found in joint fluids serum and various body fluids such as saliva and gingival groove fluid Although it is present in all periodontal tissues it is especially prominent in non-mineralized tissues such as gingiva and periodontal ligament The highly biocompatible and nonimmunogenic nature of the action of hyaluronic acid its bacteriostatic fungistatic anti-inflammatory antiedematous osteoinductive and pro-angiogenetic properties leading to the promotion of wound healing in various tissues have led hyaluronic acid to be of interest in the treatment of various diseases in medical fields such as orthopedics ophthalmology and dermatology In dentistry hyaluronic acid has been used in tooth extraction sockets temporomandibular joint treatment to accelerate the healing process and to make the healing period comfortable
Plants have always played an important role in the improvement of human health in history Hypericum perforatum a member of the Hypericaceae family has been recognized as a valuable herbal medicine This plant contains hyperforin flavonoids and hypericin The olive oil extract of H perforatum has long been used as both topical and oral medicine to treat cuts burns depression hemorrhoids diabetes and gastrointestinal ulcers Studies have shown that H perforatum increases collagen deposition shortens the duration of inflammation and stops the migration of fibroblasts during wound healing
Both agents have many areas of use that have been tried and found to be effective on wound healing It is aimed to contribute to the literature by evaluating these two agents in terms of wound healing and postoperative patient comfort in the palatal donor area and at the same time evaluating them with a control group in which no agent was used
It is aimed to investigate the postoperative effects of topical application of Hypericum perforatum L and hyaluronic acid trade names HYPERICUM PERFORATUM L Dr Özberk St Johns wort oil hyaluronic acid Gengigel Forte Gel on the healing of surgical wounds created in the palatal donor area after SDG and its effects on wound healing Hyaluronic acid is a non-sulfated polysaccharide component of the glycosaminoglycan family which is also found in joint fluids serum and various body fluids such as saliva and gingival groove fluid Although it is present in all periodontal tissues it is especially prominent in non-mineralized tissues such as gingiva and periodontal ligament The highly biocompatible and nonimmunogenic nature of the action of hyaluronic acid its bacteriostatic fungistatic anti-inflammatory antiedematous osteoinductive and pro-angiogenetic properties leading to the promotion of wound healing in various tissues have led hyaluronic acid to be of interest in the treatment of various diseases in medical fields such as orthopedics ophthalmology and dermatology In dentistry hyaluronic acid has been used in tooth extraction sockets temporomandibular joint treatment to accelerate the healing process and to make the healing period comfortable
Plants have always played an important role in the improvement of human health in history Hypericum perforatum a member of the Hypericaceae family has been recognized as a valuable herbal medicine This plant contains hyperforin flavonoids and hypericin The olive oil extract of H perforatum has long been used as both topical and oral medicine to treat cuts burns depression hemorrhoids diabetes and gastrointestinal ulcers Studies have shown that H perforatum increases collagen deposition shortens the duration of inflammation and stops the migration of fibroblasts during wound healing
Both agents have many areas of use that have been tried and found to be effective on wound healing It is aimed to contribute to the literature by evaluating these two agents in terms of wound healing and postoperative patient comfort in the palatal donor area and at the same time evaluating them with a control group in which no agent was used
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None