Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06545708
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-10
Brief Title:
Music Perception in SeLECTs
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Music and Cognitive Deficits in Self-Limited Epilepsy With Centrotemporal Spikes
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EpiMUS
Brief Summary:
Self-limited epilepsy with centrotemporal spikes SeLECTS is the most frequent epilepsy syndrome in children between the ages of 4 and 13 years SeLECTS is associated in 15 to 30 of patients with specific cognitive deficits including in particular disorders in language visuo-spatial memory declarative memory and attention SeLECTS has the potential to evolve into Landau-Kleffner syndrome the most extreme form of SeLECTS including symptoms of auditory agnosia and aphasia with potential risks of persistent neuropsychological impairments In a recent study in adults who had suffered Landau-Kleffner syndrome during childhood the investigators have shown that these patients in addition to their known deficit in verbal short-term memory also exhibit persistent musical difficulties during adulthood with in particular deficit in melody and rhythm short-term memory
In the present project the investigators intend to enlarge the understanding of cognitive deficits generated by SeLECTS in children by investigating the integrity of music perception both for melody and rhythm To date data about music perception in children with epilepsy are scarce and we do not know how distinct components of melody and rhythm perception and memory may be altered
In the present project the investigators intend to enlarge the understanding of cognitive deficits generated by SeLECTS in children by investigating the integrity of music perception both for melody and rhythm To date data about music perception in children with epilepsy are scarce and we do not know how distinct components of melody and rhythm perception and memory may be altered
Detailed Description:
Self-limited epilepsy with centrotemporal spikes SeLECTS is the most frequent epilepsy syndrome in children between the ages of 4 and 13 years The defining electroclinical feature of SeLECTS is the presence of centrotemporal spikes on EEG between seizures SeLECTS is associated with specific cognitive deficits in 15 to 30 of patients including disorders in language visuo-spatial memory explicit memory and attention The centrotemporal spikes are activated in sleep and in rare cases the condition has the potential to evolve into an Epileptic Encephalopathy with spike- and- wave activation in sleep EE-SWAS including Landau-Kleffner syndrome The latest is characterized by symptoms of auditory agnosia and aphasia with potential risks of persistent neuropsychological impairments In a previous study it has been shown that these patients also exhibit persistent musical difficulties
In the present project the investigators intend to enlarge the understanding of cognitive deficits generated by SeLECTS in children by analyzing the integrity of music perception both for melody and rhythm as well as testing the potential of a musical intervention for auditory and cognitive training in children suffering from SeLECTS
The current research plan is to explore music perception in this specific epilepsy syndrome with behavioral testing Experiment 1 and neuroimaging using functional Near-Infrared Spectroscopy fNIRS Experiment 2 and on the long run informed by this exploration and previous studies the design of a musical therapeutic intervention is envisioned in order to evaluate the impact of this program on music perception language and memory
In the present project the investigators intend to enlarge the understanding of cognitive deficits generated by SeLECTS in children by analyzing the integrity of music perception both for melody and rhythm as well as testing the potential of a musical intervention for auditory and cognitive training in children suffering from SeLECTS
The current research plan is to explore music perception in this specific epilepsy syndrome with behavioral testing Experiment 1 and neuroimaging using functional Near-Infrared Spectroscopy fNIRS Experiment 2 and on the long run informed by this exploration and previous studies the design of a musical therapeutic intervention is envisioned in order to evaluate the impact of this program on music perception language and memory
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None