Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06545747
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-04
Brief Title:
Adaptive Hypofractionated Radiotherapy for Locally Advanced NSCLC Based on Dynamic Enhanced MRI
Sponsor:
None
Organization:
None
Study Overview
Official Title:
A Randomized Controlled Phase III Study of Adaptive Hypofractionated Radiotherapy Combined With Concurrent Chemotherapy and Consolidative Immunotherapy in Locally Advanced Non-Small Cell Lung Cancer Based on Dynamic Enhanced Magnetic Resonance Imaging
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is a randomized phase III trial that aiming to investigate the role of dynamic contrast-enhanced magnetic resonance imaging DCE-MRI guided hypofractionated radiotherapy hypo-RT in patients with locally advanced non-small cell lung cancer LA-NSCLC who are planned to receive hypo-RT combined with concurrent chemotherapy and consolidative immunotherapy Patients will be randomized in a 11 ratio into two groups
1 The study group will undergo adaptive dose-painting hypo-RT based on DCE-MRI
2 The control group will undergo hypo-RT based on enhanced CT
The treatment-related toxicity local control and long-term survival will be evaluated compared between MRI-guided and CT-guided hypo-RT
1 The study group will undergo adaptive dose-painting hypo-RT based on DCE-MRI
2 The control group will undergo hypo-RT based on enhanced CT
The treatment-related toxicity local control and long-term survival will be evaluated compared between MRI-guided and CT-guided hypo-RT
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None