Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06545786
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-06
Brief Title:
Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic Analysis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic IDEA Network
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Postoperative neurocognitive disorders PND are serious and common complications after surgery especially in elderly patients These disorders can affect cognitive functions for years deteriorating quality of life and increasing hospital stays and medical costs Diagnosing PND is challenging due to their varied manifestations such as memory and attention problems and the lack of standardized criteria and biomarkers
One well-studied form of PND is postoperative delirium POD According to the ICD-10 POD is an organic cerebral syndrome characterized by disturbances in consciousness attention perception and other cognitive functions Researchers suggest that POD development involves a combination of predisposing and precipitating factors
Electroencephalography EEG has been used in anesthesiology to assess anesthesia depth and intraoperative awareness Modern EEG analysis methods like spectral analysis offer new ways to evaluate patients neurophysiological states Studies show that EEG monitoring can predict complications such as intraoperative stroke and delirium particularly in cardiothoracic and neurosurgical operations
The relationship between EEG patterns and POD is not well understood Specific EEG patterns may indicate the risk of POD aiding in the identification of risk factors and prevention methods This could help anesthesiologists and surgeons optimize their approaches reducing the risk of cognitive complications
One well-studied form of PND is postoperative delirium POD According to the ICD-10 POD is an organic cerebral syndrome characterized by disturbances in consciousness attention perception and other cognitive functions Researchers suggest that POD development involves a combination of predisposing and precipitating factors
Electroencephalography EEG has been used in anesthesiology to assess anesthesia depth and intraoperative awareness Modern EEG analysis methods like spectral analysis offer new ways to evaluate patients neurophysiological states Studies show that EEG monitoring can predict complications such as intraoperative stroke and delirium particularly in cardiothoracic and neurosurgical operations
The relationship between EEG patterns and POD is not well understood Specific EEG patterns may indicate the risk of POD aiding in the identification of risk factors and prevention methods This could help anesthesiologists and surgeons optimize their approaches reducing the risk of cognitive complications
Detailed Description:
Postoperative Neurocognitive Disorders PND are one of the most serious and common complications following surgery especially in elderly patients Postoperative neurocognitive disorders can impact cognitive functions for a prolonged period post-surgery sometimes lasting several years This not only deteriorates the quality of life but also increases hospitalization time and medical costs
The difficulty in diagnosing postoperative neurocognitive disorders is that postoperative neurocognitive disorders can manifest in various forms including memory attention and executive function problems The lack of standardized diagnostic criteria and clear biomarkers complicates early identification and prognosis of postoperative neurocognitive disorders
One of the most studied forms of postoperative neurocognitive disorders is postoperative delirium POD Currently the concept of postoperative delirium development suggests a combination of predisposing and precipitating factors Furthermore according to the ICD-10 postoperative delirium is defined as an etiologically nonspecific organic cerebral syndrome characterized by disturbances in consciousness attention perception thinking memory psychomotor behavior emotions and the sleep-wake cycle The indication of an organic nature of the lesion prompts researchers to explore the possibility of diagnosing brain dysfunctions clinically manifesting as postoperative delirium
Electroencephalography EEG has long been used in anesthesiology to assess the depth of anesthesia and the risk of awareness during surgery With the use of modern analysis algorithms such as spectral analysis and synchronization between different brain regions electroencephalography opens new horizons for assessing the patients neurophysiological state Currently the use of electroencephalography for monitoring cerebral perfusion and oxygenation is being studied which is especially critical during cardiothoracic and neurosurgical operations One study showed that a new interhemispheric similarity index in electroencephalography could serve as an indicator of the risk of complications such as intraoperative stroke and delirium after cardiac surgery These data demonstrate the possibility of using electroencephalography monitoring as a tool for predicting adverse neurocognitive outcomes
The relationship between electroencephalography and postoperative delirium has not been sufficiently studied The hypothesis is that specific electroencephalography patterns may serve as indicators of the organic substrate development of postoperative delirium which may lead to the study of risk factors and methods of their prevention This in turn will allow anesthesiologists and surgeons to optimize approaches to anesthesia and surgical intervention minimizing the risk of negative cognitive consequences
The difficulty in diagnosing postoperative neurocognitive disorders is that postoperative neurocognitive disorders can manifest in various forms including memory attention and executive function problems The lack of standardized diagnostic criteria and clear biomarkers complicates early identification and prognosis of postoperative neurocognitive disorders
One of the most studied forms of postoperative neurocognitive disorders is postoperative delirium POD Currently the concept of postoperative delirium development suggests a combination of predisposing and precipitating factors Furthermore according to the ICD-10 postoperative delirium is defined as an etiologically nonspecific organic cerebral syndrome characterized by disturbances in consciousness attention perception thinking memory psychomotor behavior emotions and the sleep-wake cycle The indication of an organic nature of the lesion prompts researchers to explore the possibility of diagnosing brain dysfunctions clinically manifesting as postoperative delirium
Electroencephalography EEG has long been used in anesthesiology to assess the depth of anesthesia and the risk of awareness during surgery With the use of modern analysis algorithms such as spectral analysis and synchronization between different brain regions electroencephalography opens new horizons for assessing the patients neurophysiological state Currently the use of electroencephalography for monitoring cerebral perfusion and oxygenation is being studied which is especially critical during cardiothoracic and neurosurgical operations One study showed that a new interhemispheric similarity index in electroencephalography could serve as an indicator of the risk of complications such as intraoperative stroke and delirium after cardiac surgery These data demonstrate the possibility of using electroencephalography monitoring as a tool for predicting adverse neurocognitive outcomes
The relationship between electroencephalography and postoperative delirium has not been sufficiently studied The hypothesis is that specific electroencephalography patterns may serve as indicators of the organic substrate development of postoperative delirium which may lead to the study of risk factors and methods of their prevention This in turn will allow anesthesiologists and surgeons to optimize approaches to anesthesia and surgical intervention minimizing the risk of negative cognitive consequences
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None