Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06546774
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-01
Brief Title:
The Effect of Melatonin Supplementation on Cumulus Cells and IVF Outcomes
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effect of Melatonin Supplementation on Cumulus Cells and Reproductive Outcomes in Older Women Undergoing IVF Cycles
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization IVF outcomes in women over 35 years old In the study group patients will receive melatonin supplementation for at least two months prior to their IVF cycles Cumulus cells will be collected after oocyte retrieval and IVF outcomes will be assessed
Detailed Description:
Aging in female reproductive cells particularly cumulus granulosa cells is associated with various dysfunctions that compromise fertility Melatonin a hormone primarily produced by the pineal gland is renowned for its multifaceted roles in regulating physiological processes including sleep-wake cycles immune function and antioxidative defense Melatonins antioxidant action is mediated through direct scavenging of free radicals upregulation of antioxidant enzymes and improvement of mitochondrial efficiency These properties make melatonin a promising candidate for mitigating the adverse effects of aging on cellular function This study aims to explore the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization IVF outcomes in women over 35 years old In the study group patients will receive melatonin supplementation for at least two months prior to their IVF cycles In the control group patients will proceed directly to IVF cycles without melatonin supplementation Cumulus cells will be collected after oocyte retrieval and gene expression will be measured Additionally clinical pregnancy rate live birth rate and miscarriage rate between the two groups will be evaluated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None