Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06550726
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-05
Brief Title:
High-resolution Multi-parametric Magnetic Resonance Imaging for Focal Epilepsy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
High-resolution Multi-parametric Magnetic Resonance Imaging for Focal Epilepsy
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with focal epilepsy often have diagnostic difficulties as their culprit for seizures are difficult to be picked up using conventional imaging The current study is to investigate the utility of advanced MRI sequences on detection of subtle lesions accountable for focal epilepsy
Detailed Description:
Focal epilepsy refers to having seizures arising from a specific part of the brain In these patients workup in magnetic resonance imaging is often necessary as patients with structural lesions have a much higher rate of seizures ranging from 10 to 26 at 1 year and from 29 to 48 at 5 years However there is also a subgroup of patients who has epilepsy not adequately controlled by anti-epileptics with unrevealing first MRI study a dedicated MRI protocol may reveal positive lesion in 30-65 of the cases In these patients several tricks can be applied to increase the detection rate First the used of a high-resolution MRI on a high-field scanner could be helpful which can be increased the sensitivity up to 90 The use of 7T-MRI in further picking up subtle lesions in patients presenting with epilepsy has been investigated further affirming the role of high resolution MRI imaging Secondly the use of dedicated sequences such as T1-weighted inversion recovery sequences which allow better distinction of grey and white matter could also reveal subtle lesions such as polymicrogyria or Type 1 focal cortical dysplasia
This study is therefore aimed to apply the findings to the local settings and specifically to investigate if T1-weighted inversion recovery sequences provides additional benefit in picking up more subtle lesions in patients who had an initial first negative MRI
This study is therefore aimed to apply the findings to the local settings and specifically to investigate if T1-weighted inversion recovery sequences provides additional benefit in picking up more subtle lesions in patients who had an initial first negative MRI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None