Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06551545
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-08
Brief Title:
Tryptophan Metabolism in Healthy Young Adults
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Tryptophan Metabolism in Healthy Young Adults in Response to Graded Tryptophan Intakes a Pilot Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Tryptophan is an essential amino acid needed for growth and bodily functions It is used to make serotonin which is needed for the brain to develop and function properly However when the body is stressed tryptophan is broken down into compounds that can cause harm to the brain Premature babies who get nutrition through their vein ie total parenteral nutrition TPN can experience this type of stress The amount of tryptophan in TPN solutions is much higher than what premature babies need and can produce too much harmful compounds So it is important to study the amount of these compounds made from tryptophan But there are no methods available to study this Therefore the goal of this study is to develop a method to measure the compounds made from tryptophan breakdown in adults so that it can be used for preterm babies on TPN later
Detailed Description:
Tryptophan is an essential amino acid and must be obtained from the diet In addition to its essential role in protein synthesis tryptophan has diverse and complex physiological functions via various metabolic pathways Two primary metabolic pathways include the kynurenine and serotonin pathways Tryptophan is the only precursor for both the kynurenine and serotonin pathways Since these two pathways share tryptophan as the common nitrogenous substrate a competition between these pathways is demonstrated This can result in serotonin deficiency when kynurenine pathway is activated and may contribute to the pathophysiology of developing neurological disease Furthermore metabolites of the kynurenine pathway can exert neurotoxic effects because they can cross the blood brain barrier to reach the central nervous system CNS Evidence thus far indicates that the contribution of the different pathways of tryptophan metabolism can differ based on the physiological and pathological status However there is no clear evidence of whether the kynurenine pathway takes precedence over synthesis of protein for growth or serotonin during immune activation There are also no investigations examining the impact of tryptophan intake during immune activation for the purposes of this study meaning any activity by the immune system on the production of neurotoxic metabolites of the kynurenine pathway
Tryptophan uptake from parenteral nutrition fed to preterm neonates with current amino acid solutions may be about 2-25 times the estimated requirement based on data from neonatal piglets Long-term effects of this excess intake in this vulnerable population are unknown The potential adverse effects of increased catabolism via the kynurenine pathway during stress on growth and neurodevelopment of hospitalized preterm infants has not been explored A method to quantify the partitioning of tryptophan between the different pathways will be highly beneficial but has not been established in humans This will enable studies in parenterally fed neonates to assess whether tryptophan concentrations in current commercial amino acid solutions produce toxic metabolites or serotonin deficiency which can contribute to neurocognitive deficits seen in this population
Tryptophan uptake from parenteral nutrition fed to preterm neonates with current amino acid solutions may be about 2-25 times the estimated requirement based on data from neonatal piglets Long-term effects of this excess intake in this vulnerable population are unknown The potential adverse effects of increased catabolism via the kynurenine pathway during stress on growth and neurodevelopment of hospitalized preterm infants has not been explored A method to quantify the partitioning of tryptophan between the different pathways will be highly beneficial but has not been established in humans This will enable studies in parenterally fed neonates to assess whether tryptophan concentrations in current commercial amino acid solutions produce toxic metabolites or serotonin deficiency which can contribute to neurocognitive deficits seen in this population
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None