Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06552663
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-10
Brief Title:
The Diagnostic Power Of Coronary CT Angiography In Patients With Chest Pain And Zero Calcium Score
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Diagnostic Power Of Coronary Ct Angiography In Patients With Chest Pain And Zero Calcium Score
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To prove the non-used wide diagnostic range of CCTA in diagnosis of other causes of chest pain in addition to the traditional known role in coronary atherosclerosis
Detailed Description:
The heart is a specialized muscular organ which receives blood via major veins SVC IVC CS then pumps it through the arteries Aorta and Pulmonary artery towards the systemic and pulmonary circulations Non oxygenated blood enters the heart via SVC IVC and CS passes to the lungs to be oxygenated via the Pulmonary artery then returns to the heart via the Pulmonary veins and finally to the systemic circulation through Aorta
Cardiac muscles are unique and differs from skeletal and smooth muscles to suit their function and they are not liable to regenerate like all cells in the body the cardiac muscles needs to be supplied with oxygen nutrients and their metabolic wastes must be drained away This is achieved by the coronary circulation which formed of two main arteries that arise just above the aortic valve These are the right and left main coronary arteries and their branches the venous drainage is through the major cardiac veins towards CS that finally drains at the right atrium 1 As a result any affection of coronary arteries or interruption of blood flow inside it will cause weakness or death of cardiac cells myocardiumThe diseases affecting coronary arteries may be congenital eg abnormal course of the coronary arteries or myocardial bridge traumatic eg dissection inflammatory eg Takayasus arteritis TAK vascular eg aneurysm lastly and the most common is atherosclerosis 2 Atherosclerosis causes variable degrees of occlusion of the coronary arteries and results in a demand-supply mismatch of oxygen it typically involves the formation of plaques in the arterial lumen of that impedes blood flow atherosclerosis may be diffuse mild subintimal affection focal or multifocal called atherosclerotic plaques Plaque is a build-up of fatty material that narrows the vessel lumen and impedes the blood flow fatty streak Which is formed by subendothelial deposition of lipid-laden macrophages foam cells smooth muscles and collagen Over time this plaque could grow in size or become stable if no further insult occurs to the endothelium If it becomes stable a fibrous cap will form and the lesion will become calcified over time The drawback of calcified plaque is stenosis that impedes the blood supply while that of soft plaque is liability to further growth detachment causing arterial occlusion or external rupture causing hemopericardium 3 So that it is an advantage of CT over coronary catheterization extra coronary lesions either vascular eg aortic dissection pulmonary embolism cardiac eg pericarditis extracardiac and mediastinal eg GERD or even pleurisy myositis and other chest pathologies via large FOV scanning through another phase Cardiovascular diseases do not frequently have symptoms but may cause chest pain which is the most important symptom in CVDs and may be a sign of other diseases like vascular inflammatory etc
In the past CADs diagnosis could be done by many tests like ECG blood tests Cardiac catheterization and angiogram Which is invasive despite of high real time value and ability to place a stent or balloon dilatation 4 Recently multidetector computed tomography CT and CT angiography could be done due to recent equipment that could match the cardiac motion and avoid the artifacts
A CT scan of the heart can show calcium deposits and blockages in the coronary arteries and be calculated by calcium score The calcium score is calculated based on the amount of calcification in the vessel walls of coronary arteries observed in a cardiac CT scan Many methods have been used in calcium scoring eg Agatston calcium score which is the most popular one A higher score indicates a larger amount of calcium deposition However Ca score of zero is not a sign of negative CVDs so that CCTA become a must and dont just depend on the coronary Ca score alone
A CT coronary angiogram is mainly used to check for narrowed or blocked coronary artery by any plaque even the soft non calcified ones However it can check for other heart conditions such congenital heart disease valvular heart disease carditis aortic aneurysmsetc
A CT coronary angiogram differs from a standard coronary angiogram Which is an invasive technique that could only see the lumen of the artery not the wall itself and calcium score is not available yet still a real time technique and have a therapeutic value at the same time 5
Cardiac muscles are unique and differs from skeletal and smooth muscles to suit their function and they are not liable to regenerate like all cells in the body the cardiac muscles needs to be supplied with oxygen nutrients and their metabolic wastes must be drained away This is achieved by the coronary circulation which formed of two main arteries that arise just above the aortic valve These are the right and left main coronary arteries and their branches the venous drainage is through the major cardiac veins towards CS that finally drains at the right atrium 1 As a result any affection of coronary arteries or interruption of blood flow inside it will cause weakness or death of cardiac cells myocardiumThe diseases affecting coronary arteries may be congenital eg abnormal course of the coronary arteries or myocardial bridge traumatic eg dissection inflammatory eg Takayasus arteritis TAK vascular eg aneurysm lastly and the most common is atherosclerosis 2 Atherosclerosis causes variable degrees of occlusion of the coronary arteries and results in a demand-supply mismatch of oxygen it typically involves the formation of plaques in the arterial lumen of that impedes blood flow atherosclerosis may be diffuse mild subintimal affection focal or multifocal called atherosclerotic plaques Plaque is a build-up of fatty material that narrows the vessel lumen and impedes the blood flow fatty streak Which is formed by subendothelial deposition of lipid-laden macrophages foam cells smooth muscles and collagen Over time this plaque could grow in size or become stable if no further insult occurs to the endothelium If it becomes stable a fibrous cap will form and the lesion will become calcified over time The drawback of calcified plaque is stenosis that impedes the blood supply while that of soft plaque is liability to further growth detachment causing arterial occlusion or external rupture causing hemopericardium 3 So that it is an advantage of CT over coronary catheterization extra coronary lesions either vascular eg aortic dissection pulmonary embolism cardiac eg pericarditis extracardiac and mediastinal eg GERD or even pleurisy myositis and other chest pathologies via large FOV scanning through another phase Cardiovascular diseases do not frequently have symptoms but may cause chest pain which is the most important symptom in CVDs and may be a sign of other diseases like vascular inflammatory etc
In the past CADs diagnosis could be done by many tests like ECG blood tests Cardiac catheterization and angiogram Which is invasive despite of high real time value and ability to place a stent or balloon dilatation 4 Recently multidetector computed tomography CT and CT angiography could be done due to recent equipment that could match the cardiac motion and avoid the artifacts
A CT scan of the heart can show calcium deposits and blockages in the coronary arteries and be calculated by calcium score The calcium score is calculated based on the amount of calcification in the vessel walls of coronary arteries observed in a cardiac CT scan Many methods have been used in calcium scoring eg Agatston calcium score which is the most popular one A higher score indicates a larger amount of calcium deposition However Ca score of zero is not a sign of negative CVDs so that CCTA become a must and dont just depend on the coronary Ca score alone
A CT coronary angiogram is mainly used to check for narrowed or blocked coronary artery by any plaque even the soft non calcified ones However it can check for other heart conditions such congenital heart disease valvular heart disease carditis aortic aneurysmsetc
A CT coronary angiogram differs from a standard coronary angiogram Which is an invasive technique that could only see the lumen of the artery not the wall itself and calcium score is not available yet still a real time technique and have a therapeutic value at the same time 5
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None