Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06554002
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-07-26
Brief Title:
Acute and Long-term Health Effects of Various Carbohydrates on Blood Glucose Management in Humans
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Acute-postprandial and Long-term Effects of Different Types of Carbohydrate on Human Health and Blood Glucose Management
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Dietary fibre especially soluble fibre has several health benefits such as lowering the risks for cardiovascular disease stroke diabetes obesity and gastrointestinal diseases Resistant dextrin is a non-viscous soluble fibre can be introduced quite easily in foods or as drinks and it is well tolerated This study aims to investigate if daily supplementation of habitual diets with resistant dextrin over 8 weeks affect glycaemic control via insulin sensitivity intestinal fermentation energy expenditure and fat oxidation in adults with increased risk for type 2 diabetes The primary outcome is the effect on glycaemic control fasting glucose insulin insulin sensitivity and 24 hour glycaemic response from CGMS The secondary outcomes are the effects on fasting lipids energy expenditure and fuel utilization in a whole room calorimeter and appetite regulation
Detailed Description:
Dietary fibre has several health benefits such as lowering the risks for cardiovascular disease stroke diabetes obesity and gastrointestinal diseases Dietary fibre intake has regularly been reported to be below the daily recommended levels Based on the 2010 National Nutrition Survey 21 of Singaporeans did not meet the recommended daily intake of dietary fibre While increasing fruit and vegetables intake remains the primary strategy to promote fibre intake an alternative is to supplement a daily diet with dietary fibre especially soluble fibre to improve health
Resistant dextrin is a non-viscous soluble fibre that exhibits prebiotic properties and it has been shown to alter gastrointestinal ecology Emerging evidence suggests that resistant dextrin reduced insulin resistance in both healthy individuals and adults with type 2 diabetes resulting in better blood glucose control In term of its cardio-protective effects resistant dextrin has also been shown to lower blood cholesterol levels and reduced inflammation biomarkers Resistant dextrin has also been shown to suppress hunger and increase satiety leading to reduced daily energy intake and greater body weight loss
To date evidence from clinical trials notably among Asians is still insufficient to make dietary recommendations In addition the possibility of short-chain fatty acid production in stimulating diet-induced thermogenesis and fat oxidation has not been explored These are the novel aspects that our proposed study aims to investigate
Resistant dextrin is a non-viscous soluble fibre that exhibits prebiotic properties and it has been shown to alter gastrointestinal ecology Emerging evidence suggests that resistant dextrin reduced insulin resistance in both healthy individuals and adults with type 2 diabetes resulting in better blood glucose control In term of its cardio-protective effects resistant dextrin has also been shown to lower blood cholesterol levels and reduced inflammation biomarkers Resistant dextrin has also been shown to suppress hunger and increase satiety leading to reduced daily energy intake and greater body weight loss
To date evidence from clinical trials notably among Asians is still insufficient to make dietary recommendations In addition the possibility of short-chain fatty acid production in stimulating diet-induced thermogenesis and fat oxidation has not been explored These are the novel aspects that our proposed study aims to investigate
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None