Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06554964
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-08
Brief Title:
Chromotubation on the Remaining Fallopian Tube After a Laparoscopic Salpingectomy Due to Tubal Pregnancy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Feasibility Safety and Effectiveness of Chromotubation on the Remaining Fallopian Tube After a Laparoscopic Salpingectomy Due to Tubal Pregnancy
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Ectopic pregnancy prevalence is approximately 1-2 of all pregnancies majority of which located in the fallopian tube Among the risk factors for ectopic pregnancy is tubal factor - meaning a mechanical problem within the fallopian tube resulting in the pregnancy remaining in the fallopian tube The treatment o tubal pregnancy can be expectant medical via metotrexate or surgicl via laparoscopic salpingectomy of the involved fallopian tube The purpose of this study is to assess the feasibility of chromotubation during laparoscopic salpingectomy for the surgical management of tubal ectopic pregnancy hence assessing the function of the remaining fallopian tube and trying to predict future fertility for the patient
Detailed Description:
Ectopic pregnancy occurs approximately in 1-2 of all pregnancies The risk is higher among patients with risk factors such as previous ectopic pregnancy history of pelvic inflammatory disease endometriosis past tubal surgery pregnancy following in vitro fertilization and pregnancy conceived with an intrauterine device In 97 of the cases the location of the ectopic pregnancy would be in the fallopian tube The management of fallopian tube ectopic pregnancy can be expectant medical with intramuscular methotrexate or surgical via laparoscopic salpingectomy of the involved fallopian tube The optimal management is chosen depending on the clinical presentation sonographic and laboratory findings and patients wishes
Laparoscopic salpingectomy is indicated in cases of suspected ruptured ectopic pregnancy Salpingectomy is also offered in cases of recurrent ipsilateral ectopic pregnancy contraindications to medical management with methotrexate and patients who prefer surgical over medical treatment
The risk of recurrent ectopic tubal pregnancy following unilateral laparoscopic salpingectomy varies according to the functionality of the remaining fallopian tube and between different studies In cases of an abnormal contralateral fallopian tube the risk of recurrent tubal pregnancy is high For patients with a healthy contralateral fallopian tube some studies found that the long-term fertility after salpingectomy was not significantly impacted while other studies reported a mild reduction in natural conception rates Thus it is estimated that a functional remaining fallopian tube may capture oocytes from both ovaries and may compensate for the loss of the other fallopian tube Overall the patency and functionality of the remaining fallopian tube is the most important factor in determining the risk of recurrent ectopic pregnancy and the rates of subsequent natural intrauterine conception
Chromotubation is a procedure used in order to assess the patency of the fallopian tubes mostly at time of laparoscopy under general anesthesia It involves the injection of colored blue dye mostly methylene blue or indigo carmine through the cervix and into the uterine cavity and the fallopian tubes During laparoscopy the flow of the dye through the fallopian tubes may be observed and the patency of the fallopian tubes may be determined
The intracervical use of methylene blue or indigo-carmine for laparoscopic chromotubation is generally considered safe Rare adverse reactions were described among patients with G6PD deficiency for whom methylene blue may cause hemolysis and for patient who are treated with SSRI for whom methylene blue may cause serotonin toxicity due to inhibition of monoamine oxidase
Other methods to evaluate the patency of the fallopian tubes include hysterosalpingogram HSG and ultrasound guided perturbation using Exfoam These imaging procedures are performed without anesthesia and may be associated with pain and discomfort and their results may be inconclusive because of tubal spasm Thus laparoscopic chromotubation which allows for the evaluation of tubal patency and pelvic anatomy is considered the gold standard procedure
The current practice in the management of patients undergoing laparoscopic salpingectomy for tubal pregnancy includes observation of the pelvic and tubal anatomy at time of surgery followed by referral for outpatient assessment of tubal patency by HSG or by ultrasound at a later date usually after 2 months
In the current study the investigators propose to perform an evaluation of tubal patency by laparoscopic chromotubation at time of laparoscopic salpingectomy for tubal pregnancy The investigators will assess the feasibility of the procedure ie whether tubal patency may be determined in this setting and its safety
Laparoscopic salpingectomy is indicated in cases of suspected ruptured ectopic pregnancy Salpingectomy is also offered in cases of recurrent ipsilateral ectopic pregnancy contraindications to medical management with methotrexate and patients who prefer surgical over medical treatment
The risk of recurrent ectopic tubal pregnancy following unilateral laparoscopic salpingectomy varies according to the functionality of the remaining fallopian tube and between different studies In cases of an abnormal contralateral fallopian tube the risk of recurrent tubal pregnancy is high For patients with a healthy contralateral fallopian tube some studies found that the long-term fertility after salpingectomy was not significantly impacted while other studies reported a mild reduction in natural conception rates Thus it is estimated that a functional remaining fallopian tube may capture oocytes from both ovaries and may compensate for the loss of the other fallopian tube Overall the patency and functionality of the remaining fallopian tube is the most important factor in determining the risk of recurrent ectopic pregnancy and the rates of subsequent natural intrauterine conception
Chromotubation is a procedure used in order to assess the patency of the fallopian tubes mostly at time of laparoscopy under general anesthesia It involves the injection of colored blue dye mostly methylene blue or indigo carmine through the cervix and into the uterine cavity and the fallopian tubes During laparoscopy the flow of the dye through the fallopian tubes may be observed and the patency of the fallopian tubes may be determined
The intracervical use of methylene blue or indigo-carmine for laparoscopic chromotubation is generally considered safe Rare adverse reactions were described among patients with G6PD deficiency for whom methylene blue may cause hemolysis and for patient who are treated with SSRI for whom methylene blue may cause serotonin toxicity due to inhibition of monoamine oxidase
Other methods to evaluate the patency of the fallopian tubes include hysterosalpingogram HSG and ultrasound guided perturbation using Exfoam These imaging procedures are performed without anesthesia and may be associated with pain and discomfort and their results may be inconclusive because of tubal spasm Thus laparoscopic chromotubation which allows for the evaluation of tubal patency and pelvic anatomy is considered the gold standard procedure
The current practice in the management of patients undergoing laparoscopic salpingectomy for tubal pregnancy includes observation of the pelvic and tubal anatomy at time of surgery followed by referral for outpatient assessment of tubal patency by HSG or by ultrasound at a later date usually after 2 months
In the current study the investigators propose to perform an evaluation of tubal patency by laparoscopic chromotubation at time of laparoscopic salpingectomy for tubal pregnancy The investigators will assess the feasibility of the procedure ie whether tubal patency may be determined in this setting and its safety
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None