Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06556030
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-13
Brief Title:
A Multicentre Randomised Single-blind Controlled Protocol to Evaluate the Efficacy of Early Administration of Botulinum Toxin for Primary Midline Closure in Patients With Open Abdomen
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Botulinum Toxin in Open Abdomen Closure
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BOTU-CLOSURE
Brief Summary:
A multicentre randomised single-blind controlled protocol to evaluate the efficacy of early administration of botulinum toxin for primary midline closure in patients with open abdomen Early use less than 48 hours of botulinum toxin as a neuromuscular abdominal wall blocker in patients whose abdomen is left open regardless of the cause will improve postoperative outcome and prognosis leading to significantly higher percentages of primary midline closure
Detailed Description:
According to the definition of the World Society for Emergency Surgery WSES an open abdomen is defined as the intentional creation of a laparostomy by non-approximation of the aponeurotic edges of the rectus abdominis muscles in the midline 1 This technique is restricted to very specific situations usually in the critically ill patient who has undergone damage control surgery for polytrauma abdominal sepsis or abdominal compartment syndrome In this context it may be necessary to keep the abdomen open for four indications that were defined in 2015 by an international consensus of experts
need for reintervention second-look in cases of ischaemia or severe intra-abdominal contamination inability to close due to visceral oedema traumatic damage to the abdominal wall failure of medical treatment in the management of abdominal compartment syndrome 2
Since its description in 1993 although open abdomen was used for abdominal compartment syndrome decades earlier the use of damage control surgery associated with intensive resuscitation has decreased mortality in these patients from 90 to approximately 20-30 today 3
Despite its benefits for the survival of unstable patients the creation of an open abdomen creates a non-anatomical situation with significant physiological repercussions exposure of the abdominal viscera to the environment without barrier mechanisms results in hypothermia and significant fluid and protein loss precipitating a catabolic state that feeds back into the multi-organ failure of the critically ill patient In addition the open abdomen leads to potentially very serious complications such as the development of an enteroatmospheric fistula which occurs in up to 15 of these patients 245
In order to reduce complications and simplify the management of patients with open abdomen various temporary closure devices have been developed 5 Among them current evidence recommends the use of negative pressure devices generally consisting of a sheet of non-absorbable plastic material in contact with the viscera that tries to prevent the appearance of adhesions and fistulas and which by presenting small perforations allows intra-abdominal fluid to escape a macroporous material that remains in lateral contact with the fascia and subcutaneous tissue and a final occlusive cover to which suction is applied to generate the negative pressure The incorporation of these devices has been shown to reduce the production of proinflammatory cytokines in the peritoneal fluid 6 and the aforementioned guidelines recommend their use in all cases of open abdomen grade of recommendation B level of evidence I2
However no temporary closure technique to date has been able to restore the physiological situation altered by having an open abdomen and therefore all efforts should be directed towards keeping the duration of the open abdomen as short as possible
There is a direct relationship between the duration of the open abdomen and the number of dressings or revisions required until closure and the appearance of complications such as enteroatmospheric fistula 7 Although some temporary closure techniques can lengthen this time until the appearance of fistulas it is generally established that the risk of fistula is very high after one week of open abdomen 8
Another negative effect of open abdomen occurs at the level of the abdominal wall as there is no continuity of the wall the lateral musculature of the abdominal wall external internal and transverse oblique muscles is functionally 34disinserted34 from its insertion in the midline and naturally tends to retract as time goes by thus separating the rectus abdominis muscles and hindering the eventual reconstruction of the midline when the patient39s situation allows it
In order to achieve greater primary fascial closure various techniques have been described in association with temporary closures to prevent muscle retraction The most common form is the interposition between the temporary closure materials of sutures or meshes anchored to both fascial ends This not only prevents retraction but in successive revision surgeries the tension on the musculature can be progressively increased to achieve closure after a few days This is known as sequential closure or delayed primary closure as the duration until complete closure is achieved is usually longer than 7 days generally around 13-15 49
Another resource available to achieve fascial closure is to associate component separation techniques commonly anterior component separation However these manoeuvres are associated with greater complications at the abdominal wall level such as haematoma formation The third way would be to suture both ends of the fascia to a mesh that would be interposed between them containing the viscera which in the literature has been called bridging generally with a resorbable mesh The subsequent occurrence of an eventration is greater than 50 but it allows the abdominal wall to be closed and the defect to be addressed in a planned manner at a later date 10
In summary making the decision to leave an open abdomen is a race against time in which the longer it takes for the patient39s clinical situation to allow closure the more complications can occur and the more difficult it is to achieve repair The literature describes highly variable rates of primary fascial closure with the best results being the combination of vacuum devices associated with traction techniques with rates of up to 80 1112 Even within the same multicentre study with a closure rate of 655 the range among participating centres was 255 to 852 13 It should also be noted that these patients have a high risk of subsequent eventration with published rates of 35 at 4 years 14 Closure at the first surgical revision is achieved in only one third of patients but these patients have fewer complications 15
Botulinum toxin is a bacterial neurotoxin Cl botulinum responsible for botulism There are eight varieties of neurotoxin all of which share the same mechanism of action blocking the release of acetylcholine at the motor plate at the neuromuscular junction generating a chemical denervation that is reversible Medical applications have been described since the last decades of the last century
of botulinum toxin infiltration for the treatment of muscle dystonia and also for aesthetic purposes 16
In abdominal wall surgery the use of botulinum toxin was first described in 2009 17 As mentioned its effect is reversible becoming noticeable in experimental studies after 1-2 days reaching a maximum after 3-4 weeks and disappearing after 6-9 months Due to this dynamic its application has been mainly in the context of elective surgery in patients with large hernia defects infiltrating the lateral musculature weeks before the operation In this field there are publications with good quality evidence 18 that support its use in patients with large eventrations and loss of domicile alone or in combination with progressive pneumoperitoneum 19
In the context of open abdomen and damage control surgery the time to onset of significant paralysis and the clinical situation of the patients which guides the timing and indication for reinterventions have been the main factors limiting its applicability The first mention of this indication was found in 2013 by Zielinski39s group who published a series of 18 patients who underwent infiltration with 300 IU of BTX in the external internal and transverse oblique of the abdomen bilaterally Primary fascial closure was achieved in 83 bridging in another 6 and skin closure and formation of a planned eventration in 11 Subsequent complications included 11 early dehiscence 20 However in 2016 the same group published a pilot clinical trial in which the use of botulinum toxin did not significantly differ from the placebo group This clinical trial had very restrictive exclusion criteria and consequently obtained primary closure figures with and without the use of toxin of over 90 that do not correspond to those described in other studies which in the words of the authors themselves suggests a possible type II error 21 In addition to these studies there are retrospective case series that provide favourable data without showing an increase in complications 22 All this is summarised in the systematic review of the literature published in 2022 23 the use of botulinum toxin seems to offer advantages in the context of the open abdomen without a high risk profile although quality studies are needed to provide information on effectiveness based on a population that is more representative of reality
need for reintervention second-look in cases of ischaemia or severe intra-abdominal contamination inability to close due to visceral oedema traumatic damage to the abdominal wall failure of medical treatment in the management of abdominal compartment syndrome 2
Since its description in 1993 although open abdomen was used for abdominal compartment syndrome decades earlier the use of damage control surgery associated with intensive resuscitation has decreased mortality in these patients from 90 to approximately 20-30 today 3
Despite its benefits for the survival of unstable patients the creation of an open abdomen creates a non-anatomical situation with significant physiological repercussions exposure of the abdominal viscera to the environment without barrier mechanisms results in hypothermia and significant fluid and protein loss precipitating a catabolic state that feeds back into the multi-organ failure of the critically ill patient In addition the open abdomen leads to potentially very serious complications such as the development of an enteroatmospheric fistula which occurs in up to 15 of these patients 245
In order to reduce complications and simplify the management of patients with open abdomen various temporary closure devices have been developed 5 Among them current evidence recommends the use of negative pressure devices generally consisting of a sheet of non-absorbable plastic material in contact with the viscera that tries to prevent the appearance of adhesions and fistulas and which by presenting small perforations allows intra-abdominal fluid to escape a macroporous material that remains in lateral contact with the fascia and subcutaneous tissue and a final occlusive cover to which suction is applied to generate the negative pressure The incorporation of these devices has been shown to reduce the production of proinflammatory cytokines in the peritoneal fluid 6 and the aforementioned guidelines recommend their use in all cases of open abdomen grade of recommendation B level of evidence I2
However no temporary closure technique to date has been able to restore the physiological situation altered by having an open abdomen and therefore all efforts should be directed towards keeping the duration of the open abdomen as short as possible
There is a direct relationship between the duration of the open abdomen and the number of dressings or revisions required until closure and the appearance of complications such as enteroatmospheric fistula 7 Although some temporary closure techniques can lengthen this time until the appearance of fistulas it is generally established that the risk of fistula is very high after one week of open abdomen 8
Another negative effect of open abdomen occurs at the level of the abdominal wall as there is no continuity of the wall the lateral musculature of the abdominal wall external internal and transverse oblique muscles is functionally 34disinserted34 from its insertion in the midline and naturally tends to retract as time goes by thus separating the rectus abdominis muscles and hindering the eventual reconstruction of the midline when the patient39s situation allows it
In order to achieve greater primary fascial closure various techniques have been described in association with temporary closures to prevent muscle retraction The most common form is the interposition between the temporary closure materials of sutures or meshes anchored to both fascial ends This not only prevents retraction but in successive revision surgeries the tension on the musculature can be progressively increased to achieve closure after a few days This is known as sequential closure or delayed primary closure as the duration until complete closure is achieved is usually longer than 7 days generally around 13-15 49
Another resource available to achieve fascial closure is to associate component separation techniques commonly anterior component separation However these manoeuvres are associated with greater complications at the abdominal wall level such as haematoma formation The third way would be to suture both ends of the fascia to a mesh that would be interposed between them containing the viscera which in the literature has been called bridging generally with a resorbable mesh The subsequent occurrence of an eventration is greater than 50 but it allows the abdominal wall to be closed and the defect to be addressed in a planned manner at a later date 10
In summary making the decision to leave an open abdomen is a race against time in which the longer it takes for the patient39s clinical situation to allow closure the more complications can occur and the more difficult it is to achieve repair The literature describes highly variable rates of primary fascial closure with the best results being the combination of vacuum devices associated with traction techniques with rates of up to 80 1112 Even within the same multicentre study with a closure rate of 655 the range among participating centres was 255 to 852 13 It should also be noted that these patients have a high risk of subsequent eventration with published rates of 35 at 4 years 14 Closure at the first surgical revision is achieved in only one third of patients but these patients have fewer complications 15
Botulinum toxin is a bacterial neurotoxin Cl botulinum responsible for botulism There are eight varieties of neurotoxin all of which share the same mechanism of action blocking the release of acetylcholine at the motor plate at the neuromuscular junction generating a chemical denervation that is reversible Medical applications have been described since the last decades of the last century
of botulinum toxin infiltration for the treatment of muscle dystonia and also for aesthetic purposes 16
In abdominal wall surgery the use of botulinum toxin was first described in 2009 17 As mentioned its effect is reversible becoming noticeable in experimental studies after 1-2 days reaching a maximum after 3-4 weeks and disappearing after 6-9 months Due to this dynamic its application has been mainly in the context of elective surgery in patients with large hernia defects infiltrating the lateral musculature weeks before the operation In this field there are publications with good quality evidence 18 that support its use in patients with large eventrations and loss of domicile alone or in combination with progressive pneumoperitoneum 19
In the context of open abdomen and damage control surgery the time to onset of significant paralysis and the clinical situation of the patients which guides the timing and indication for reinterventions have been the main factors limiting its applicability The first mention of this indication was found in 2013 by Zielinski39s group who published a series of 18 patients who underwent infiltration with 300 IU of BTX in the external internal and transverse oblique of the abdomen bilaterally Primary fascial closure was achieved in 83 bridging in another 6 and skin closure and formation of a planned eventration in 11 Subsequent complications included 11 early dehiscence 20 However in 2016 the same group published a pilot clinical trial in which the use of botulinum toxin did not significantly differ from the placebo group This clinical trial had very restrictive exclusion criteria and consequently obtained primary closure figures with and without the use of toxin of over 90 that do not correspond to those described in other studies which in the words of the authors themselves suggests a possible type II error 21 In addition to these studies there are retrospective case series that provide favourable data without showing an increase in complications 22 All this is summarised in the systematic review of the literature published in 2022 23 the use of botulinum toxin seems to offer advantages in the context of the open abdomen without a high risk profile although quality studies are needed to provide information on effectiveness based on a population that is more representative of reality
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None