Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06557473
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-13
Brief Title:
Lidocaine Versus Fentanyl for Hemodynamic Stability
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Hemodynamic Stability of Fentanyl Based Versus Lidocaine Based Induction of Anesthesia in Hypertensive Adults
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hypertension is an important health challenge that affects millions of people across the world today and is a major risk factor for multiple system comorbidities Intraoperative hypotension may lead to negative outcomes Post-induction hypotension PIH ie arterial hypotension defined as hypotension during the first 20 min after anesthesia induction or from anesthesia induction until the beginning of surgery and early intraoperative hypotension eIOH ie arterial hypotension occurring during the first 30 min of surgery Lidocaine is a local anesthetic drug with multiple systemic uses Systemic lidocaine used as at the perioperative period has analgesic and anti-inflammatory properties which make it capable of reducing intra- and postoperative drug consumptions and patients hospital stay Therefore we hypothesize that the use of lidocaine as an adjuvant to propofol might reduce the risk of post induction hypotension and hence having more stable hemodynamic profile during induction of anesthesia
Detailed Description:
Since post induction hypotension is mainly caused by anesthetic drugs developing a technique for the induction of anesthesia that provides adequate hypnosis with stable hemodynamics during surgery is critical especially for hypertensive patients 4 Propofol is the most commonly used drug for anesthesia induction however its use is usually associated with hypotension through vasodilation and direct myocardial depression 5 Opioid drugs are usually added to propofol to potentiate its hypnotic effect however they also potentiate propofols negative hemodynamic effect at the same degree even with low doses of propofol 5
Lidocaine is a local anesthetic drug with multiple systemic uses Systemic lidocaine used as at the perioperative period has analgesic and anti-inflammatory properties which make it capable of reducing intra- and postoperative drug consumptions and patients hospital stay 6 Lidocaineketamine combination showed a favorable hemodynamic profile following rapid-sequence induction of anesthesia in septic shock patients 14 Therefore we hypothesize that the use of lidocaine as an adjuvant to propofol might reduce the risk of post induction hypotension and hence having more stable hemodynamic profile during induction of anesthesia
Lidocaine is a local anesthetic drug with multiple systemic uses Systemic lidocaine used as at the perioperative period has analgesic and anti-inflammatory properties which make it capable of reducing intra- and postoperative drug consumptions and patients hospital stay 6 Lidocaineketamine combination showed a favorable hemodynamic profile following rapid-sequence induction of anesthesia in septic shock patients 14 Therefore we hypothesize that the use of lidocaine as an adjuvant to propofol might reduce the risk of post induction hypotension and hence having more stable hemodynamic profile during induction of anesthesia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None