Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06557642
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-19
Brief Title:
Nitrous Oxide and EMOtional Cognition
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Investigating the Neuropsychological Effects of Nitrous Oxide
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NEMO
Brief Summary:
The goal of this study is to uncover the underlying neuropsychological mechanisms of nitrous oxide which may be relevant to its reported antidepressant effects In particular the study is designed to determine whether nitrous oxide changes the way in which healthy volunteers aged 18-40 years remember negative autobiographical memories
The main question the study aims to answer is
Does nitrous oxide interfere with the emotional aspects of negative autobiographical memories
Other neuropsychological effects will also be assessed eg emotional processing emotional memory response inhibition and cognitive flexibility
Researchers will compare ENTONOX 50 nitrous oxide 50 oxygen with medical air
Participants will
Attend three research visits screening inhalation follow-up
Take part in a 30 minute inhalation session of ENTONOX or medical air
Complete a series of cognitive tasks
Finish a series of self-report questionnaires
The main question the study aims to answer is
Does nitrous oxide interfere with the emotional aspects of negative autobiographical memories
Other neuropsychological effects will also be assessed eg emotional processing emotional memory response inhibition and cognitive flexibility
Researchers will compare ENTONOX 50 nitrous oxide 50 oxygen with medical air
Participants will
Attend three research visits screening inhalation follow-up
Take part in a 30 minute inhalation session of ENTONOX or medical air
Complete a series of cognitive tasks
Finish a series of self-report questionnaires
Detailed Description:
Questions regarding the mechanisms of nitrous oxide and its effects on the brain and behaviour in the context of its reported antidepressant effects remain largely unanswered Thus in the present study the investigators aim to elucidate the more general effects that nitrous oxide might have on a series of neurocognitive processes which may be relevant to the treatment of depression Namely the study will investigate 1 reconsolidation of autobiographical memories 2 measures of emotional processing and emotional memory 3 response inhibition 4 cognitive flexibility and 5 sleep stages
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None