Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06557707
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-05-30
Brief Title:
Cardiovascular Health Early Stress
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Cardiovascular Health Early Stress
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Childhood adversity is highly prevalent with 59 of the US population reporting at least one adverse childhood experience ACE Substantial evidence links childhood adversity to cardiometabolic disease later in the life course including heart disease diabetes and stroke which are 3 of the top 10 causes of mortality in the United States
ACEs encompass many possible traumatic and distressing experiences including abuse neglect or severe household dysfunctions It is not surprising that the experience of those extreme events during the first decade of life has tremendous implications for the individuals psychological and physical health
ACEs encompass many possible traumatic and distressing experiences including abuse neglect or severe household dysfunctions It is not surprising that the experience of those extreme events during the first decade of life has tremendous implications for the individuals psychological and physical health
Detailed Description:
Current knowledge supports that ACEs trigger emotional stress anxiety fear and discomfort in the individual Acute and intense mental stress leads to structural changes in the amygdala prolonged activation of the hypothalamic-pituitary-adrenal axis and hyperactivation of the sympathetic nervous system Then the body secretes hormones to activate the cardiovascular system to cope with stress with a rapid increase in arterial pressure and heart rate If the trauma is severe andor repeated the resting state for heart rate and blood pressure are readjusted resulting in these children living in a heightened physiological state of arousal including higher heart and respiration rates This status leads to endothelial dysfunction and atherothrombotic activation that can contribute to premature cardiovascular dysfunctions Notably there is evidence of a cumulative effect or dose-response relationship between the number of reported ACEs and the prevalence of health risk behaviors and chronic diseases Thus despite the prevalence of ACEs and the impact on health and society the mechanisms underlying these dysfunctions are still poorly understood The present study aims to understand the impact of different types of ACEs on cardiovascular health
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None