Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06558578
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-08-09
Brief Title:
Association of Helicobacter Pylori Infection and Migraine
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Association of Helicobacter Pylori Infection and Migraine in Children and Adolescent
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study aims to assess the relation between migraine and H pylori infection in children and adolescent
Detailed Description:
Migraine is one of the most common types of headaches worldwide affecting 12-15 of the world population more common in women and also the main headache for which patients refer to specialist nerve clinics
Migraine is a complex neurovascular condition involving vasodilatation of intracranial and extracerebral blood vessels This results in activation of trigeminal sensory nervous pain pathway leading to headache Serotonin and reserpine serotonin evacuator play a notable role in the development of migraine headache by increasing cerebral blood flow
Migraine is characterized by episodic attack that may be moderate to severe in intensity focal in nature have a throbbing quality Compared to adults pediatric migraine is shorter in duration and often has bilateral bifrontal in the point of location
Migraine is divided into two main types of migraine are migraine with aura in which patients experience transient visual or sensory symptoms including flickering lights spots or pins that develop 5-20 minutes before attacks occurring in approximately 25 of patients with migraine and migraine without aura occurring in the remaining 75 of patients
Helicobacter pylori infection is a significant risk factor for migraine with no observational difference between two types migraine with and without aura Eradication treatment was helpful on the clinical improvement of pain
H pylori is a gram-negative microaerophilic spiral bacterium with increased motility by multiple unipolar flagella It generates urease and colonizes the mucus layer adjacent to the gastric mucosa usually being responsible for gastrointestinal impairments such as chronic active gastroenteritis infection gastric and duodenal ulcer and more rarely stomach cancer also may be the result of various extra-digestive conditions such as neurological cardiovascular metabolic hematologic ocular or dermatological ones
A research explained that gastrointestinal neuroendocrine cells such as enterochromaffin cells EC cells can synthesize and secrete serotonin 5-hydroxytryptamine 5-HT and some factors that motivate the cell to secrete 5-HT can cause central nervous system CNS perturbation via the brain-gut axis Inflammation motivates the cell to secrete 5-HT eg when H pylori infect a cell Eradication of H pylori infection has helpful outcomes to improve clinical attacks by the effect of eradication therapy on the inflammation induced high levels of 5-HT
Other theory suggests that during the infection superoxide radicals and NO are produced and prolonged oxidative injury caused by the persistent infection might be involved in regional cerebral flow changes during migraine
Migraine is a complex neurovascular condition involving vasodilatation of intracranial and extracerebral blood vessels This results in activation of trigeminal sensory nervous pain pathway leading to headache Serotonin and reserpine serotonin evacuator play a notable role in the development of migraine headache by increasing cerebral blood flow
Migraine is characterized by episodic attack that may be moderate to severe in intensity focal in nature have a throbbing quality Compared to adults pediatric migraine is shorter in duration and often has bilateral bifrontal in the point of location
Migraine is divided into two main types of migraine are migraine with aura in which patients experience transient visual or sensory symptoms including flickering lights spots or pins that develop 5-20 minutes before attacks occurring in approximately 25 of patients with migraine and migraine without aura occurring in the remaining 75 of patients
Helicobacter pylori infection is a significant risk factor for migraine with no observational difference between two types migraine with and without aura Eradication treatment was helpful on the clinical improvement of pain
H pylori is a gram-negative microaerophilic spiral bacterium with increased motility by multiple unipolar flagella It generates urease and colonizes the mucus layer adjacent to the gastric mucosa usually being responsible for gastrointestinal impairments such as chronic active gastroenteritis infection gastric and duodenal ulcer and more rarely stomach cancer also may be the result of various extra-digestive conditions such as neurological cardiovascular metabolic hematologic ocular or dermatological ones
A research explained that gastrointestinal neuroendocrine cells such as enterochromaffin cells EC cells can synthesize and secrete serotonin 5-hydroxytryptamine 5-HT and some factors that motivate the cell to secrete 5-HT can cause central nervous system CNS perturbation via the brain-gut axis Inflammation motivates the cell to secrete 5-HT eg when H pylori infect a cell Eradication of H pylori infection has helpful outcomes to improve clinical attacks by the effect of eradication therapy on the inflammation induced high levels of 5-HT
Other theory suggests that during the infection superoxide radicals and NO are produced and prolonged oxidative injury caused by the persistent infection might be involved in regional cerebral flow changes during migraine
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None