Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06559033
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-13
Brief Title:
Determine the Frequency of Variants in the GBAPSAP Genes in Patients With MM or MGUS
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Determine the Frequency of Variants in the GBAPSAP Genes in Patients With Multiple Myeloma MM or Monoclonal Gammopathy of Undetermined Significance MGUS
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GAMY
Brief Summary:
No effective specific treatment is currently available for the management of Multiple Myeloma MM and Monoclonal Gammopathy of Undetermined Significance MGUS A better understanding of the pathophysiological mechanisms would make it possible to propose treatments specifically targeting the deregulated pathways
Detailed Description:
This study will characterise the links between rare diseases and complex chronic diseases Metabolism can be visualised as a complex network in which the various biomolecules represent metabolic nodes and are linked together by connections The number of connections at a node influences the effect of that biomolecule on the metabolic networks as a whole If a biomolecule has a large number of connections altering a metabolic pathway involving it will have an effect that will spread throughout the network On the other hand metabolic pathways with a high flux have a major impact on the homeostasis of the network Thus alteration of such a metabolic pathway cannot be without consequence a major alteration could induce a rare hereditary metabolic disease with an early-onset clinic whereas an alteration with a moderate effect could participate in the pathogenesis of complex diseases and may open up new therapeutic prospects for these tumour pathologies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None