Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06562452
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-08
Brief Title:
Evaluating the Effect of Injectable Platelet Rich Fibrin on Tooth Movement
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Evaluating the Effect of Injectable Platelet Rich Fibrin on Tooth Movement
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Introduction Prolonged orthodontic treatment can lead to challenges and unfavourable outcomes including increased risk of caries root resorption as well as gingival and periodontal diseases Acceleration of this step would reduce overall treatment time improve patient cooperation and decrease possible negative side effects The injectable platelet - rich fibrin is second generation holds the advantages of easier preparations and longer effects that is obtained through low-speed centrifugation The potential benefits of PRF have been widely investigated in regenerative dentistry and oral surgery such as tooth movement implantology oral pathology and periodontal therapy
Objective Our study aims to investigate the effectiveness of i PRF in accelerating maxillary canine retraction Subjects and method This study was a split-mouth randomized clinical trial was conducted on 31 patients 9 male 22 females age ranging 14-31 years who were treated for Class I malocclusion with the extraction of the maxillary first premolar After the leveling and alignment phase the canines were retracted with 150gm forces The i-PRF was prepared from the blood of each patient then injected immediately before canine retraction on the buccal and palatal aspects of the extraction sites Digital model were obtained at five time points before tooth extraction T0 and in the fourth week T1 eighth week T2 twelfth week T3 sixteenth week T4 from the beginning of distalization
Objective Our study aims to investigate the effectiveness of i PRF in accelerating maxillary canine retraction Subjects and method This study was a split-mouth randomized clinical trial was conducted on 31 patients 9 male 22 females age ranging 14-31 years who were treated for Class I malocclusion with the extraction of the maxillary first premolar After the leveling and alignment phase the canines were retracted with 150gm forces The i-PRF was prepared from the blood of each patient then injected immediately before canine retraction on the buccal and palatal aspects of the extraction sites Digital model were obtained at five time points before tooth extraction T0 and in the fourth week T1 eighth week T2 twelfth week T3 sixteenth week T4 from the beginning of distalization
Detailed Description:
One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement acceleration of canine retraction and space closure would reduce overall treatment time Tooth movement is essentially a biological response to a physical stimulus speeding up this response should avoid the occurrence of common iatrogenic effects such as white spot lesions caries root resorption and periodontal problems 1 Therefore attempts to accelerate tooth movement and reduce treatment duration are of great significance to both orthodontists and patients Thus various invasive and non-invasive modalities have been attempted to reduce the duration of orthodontic treatment by accelerating tooth movement such as surgical vibration pharmacological agents low-level laser therapy or other procedures 2345 However none of these procedures have yet become a gold standard method Platelet-based preparations from the patients blood provide a safe alternative to commercially available bioactive materials Platelet-rich fibrin PRF is the second generation holds the advantages of easier preparations and longer effects 6-11 The injectable platelet-rich fibrin i-PRF was developed as an advanced product of PRF by altering the centrifugation protocol by lowering the centrifugation speed and force to 700 rotations per minute within 3 minutes has many advantages over the conventional form such as higher rates of leukocyte regenerative cells and growth factors The potential benefits of PRF have been widely investigated in regenerative dentistry and oral surgery such as tooth movement implantology oral pathology and periodontal therapy 121314 Wang et al reported that i-PRF affected osteoblastic behavior remarkably by influencing its migration proliferation and differentiation This promotes cellular activity and accelerates bone turnover and healing 11
The purpose of this study was to investigate the efficiency of i-PRF in accelerating tooth movement
The purpose of this study was to investigate the efficiency of i-PRF in accelerating tooth movement
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None