Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06562621
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-13
Brief Title:
Clinical Study on the Safety and Efficacy of Novel Oncolytic Virus in the Treatment of Recurrent Malignant Glioma
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Clinical Study on the Safety and Efficacy of Novel Oncolytic Virus in the Treatment of Recurrent Malignant Glioma
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Glioma is the most common intracranial tumor Among them malignant glioma shows diffuse and infiltrating growth Although it is given a comprehensive treatment such as surgery radiotherapy and chemotherapy it is prone to relapse and there is an urgent need to explore new treatment methods Oncolytic virus is currently the worlds most cutting-edge treatment of glioma On the basis of previous research on glioma and oncolytic virus HSV-1 an engineered new oncolytic virus ON-01 containing CD gene has been constructed In vitro and in vivo animal experiments have found that it has a good therapeutic effect on malignant glioma and it has been approved by the ethics committee of Tiantan Hospital for its clinical research This project intends to study the safety and effectiveness of ON-01 in the clinic on the basis of pre-clinical trials and preclinical research clarify the oncolytic mechanism of ON-01 in the treatment of malignant glioma and explore the dissolution of brain glioma The new strategy of tumor virus treatment lays a theoretical foundation for the clinical promotion and application of ON-01 and product transformation
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None