Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06564181
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-19
Brief Title:
The Relation Between Serum Zinc and Lupus Nephritis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Relation Between Serum Zinc and Lupus Nephritis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to investigate the relation between serum zinc and lupus nephritis by search Prevalence of hypozincemia in lupus nephritis and Association between serum zinc and urea serum creatinine hemoglobin estimated glomerular filtration rate eGFR
Detailed Description:
Systemic lupus erythematosus SLE is a chronic autoimmune disease affecting various organs including the skin joints kidneys brain and heart
Lupus nephritis LN is one of the most common severe organ manifestations of SLE LN is clinically evident in 50-60 of patients with SLE and it is histologically evident in most SLE patients even those without clinical manifestations of kidney disease
LN is associated with significant morbidity and mortality in SLE patients as up to 20 of patients progress to end-stage renal disease ESRD The clinical manifestations of LN are variable ranging from asymptomatic proteinuria to a myriad of manifestations associated with nephritic and nephrotic syndromes and ESRD
Zinc is a vital micronutrient involved in numerous physiological processes including immune function antioxidant defense and cellular repair It is a cofactor for over 300 enzymes and plays critical roles in DNA synthesis protein production and cell division Zinc deficiency can impair immune function increase oxidative stress and hinder tissue repair which are all relevant factors in autoimmune diseases like SLE making its study in the context of LN particularly relevant
However further research is needed to fully understand the mechanisms and to develop evidence-based guidelines for zinc supplementation in lupus nephritis patients
Lupus nephritis LN is one of the most common severe organ manifestations of SLE LN is clinically evident in 50-60 of patients with SLE and it is histologically evident in most SLE patients even those without clinical manifestations of kidney disease
LN is associated with significant morbidity and mortality in SLE patients as up to 20 of patients progress to end-stage renal disease ESRD The clinical manifestations of LN are variable ranging from asymptomatic proteinuria to a myriad of manifestations associated with nephritic and nephrotic syndromes and ESRD
Zinc is a vital micronutrient involved in numerous physiological processes including immune function antioxidant defense and cellular repair It is a cofactor for over 300 enzymes and plays critical roles in DNA synthesis protein production and cell division Zinc deficiency can impair immune function increase oxidative stress and hinder tissue repair which are all relevant factors in autoimmune diseases like SLE making its study in the context of LN particularly relevant
However further research is needed to fully understand the mechanisms and to develop evidence-based guidelines for zinc supplementation in lupus nephritis patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None