Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06564220
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-08-19
Brief Title:
Testicular Adrenal Rest Tumor in Congenital Adrenal Hyperplasia Patients Attending Assuit University Children Hospital
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Testicular Adrenal Rest Tumor in Congenital Adrenal Hyperplasia Patients Attending Assiut University Children Hospital
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
assessment of the risk factors contributing for TART development in a male child with congenital adrenal hyperplasia
Detailed Description:
Congenital adrenal hyperplasia CAH is one of the most frequent endocrine disorders It is characterized by deficient activity of one of the enzymes necessary for adrenal Cortisol synthesis Autosomal recessive inheritance of deficient 21-hydroxylase 21 OH activity accounts for more than 90 of cases 1
One of the most important and frequently detected complications in males with congenital adrenal hyperplasia CAH is the development of testicular adrenal rest tumours TARTs 23
Testicular adrenal rest tumor is a benign tumor originating from adrenal cells within the testicles the adrenal cells migrate at 8 weeks of gestation from the urogenital ridge along with the gonadal cells to the testicle The exact mechanism underlying tumor growth and development is still not well understood 45
The correct diagnosis of TART is important for differential diagnosis with malignant testis tumors which need orchiectomy as opposed to TART usually treated exclusively with exogenous steroids 6
Although TARTs are always benign their location in the rete testis could obstructs the seminiferous tubules and causes gonadal dysfunction and infertility Therefore it is important to detect and treat TARTs at an early stage especially in adolescents or young adults 57
testicular ultrasound should be done in order to evaluate the presence of these lesions its size location and characteristics 9
TARTs in children have mostly been presented as case reports in the literature and only a limited number of studies have described the prevalence of TARTs in large populations of children 28
As not all male CAH patients are affected by this complication attempts have been made to identify the risk factors for the development of TARTs 7
One of the most important and frequently detected complications in males with congenital adrenal hyperplasia CAH is the development of testicular adrenal rest tumours TARTs 23
Testicular adrenal rest tumor is a benign tumor originating from adrenal cells within the testicles the adrenal cells migrate at 8 weeks of gestation from the urogenital ridge along with the gonadal cells to the testicle The exact mechanism underlying tumor growth and development is still not well understood 45
The correct diagnosis of TART is important for differential diagnosis with malignant testis tumors which need orchiectomy as opposed to TART usually treated exclusively with exogenous steroids 6
Although TARTs are always benign their location in the rete testis could obstructs the seminiferous tubules and causes gonadal dysfunction and infertility Therefore it is important to detect and treat TARTs at an early stage especially in adolescents or young adults 57
testicular ultrasound should be done in order to evaluate the presence of these lesions its size location and characteristics 9
TARTs in children have mostly been presented as case reports in the literature and only a limited number of studies have described the prevalence of TARTs in large populations of children 28
As not all male CAH patients are affected by this complication attempts have been made to identify the risk factors for the development of TARTs 7
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None