Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06569992
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
None
First Post:
2024-08-20
Brief Title:
Etiology and Hemodynamic Instability in Brain Death
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Comparison of the Relationship Between Etiology and Hemodynamic Instability in Brain Death VIS and TIES
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Brain death is a complex and irreversible condition marked by the cessation of all brain activity This retrospective study analyzes ICU patients who progressed from initial brain injury to brain death The research focuses on demographic profiles pharmacological interventions laboratory data and imaging findings to understand these cases clinical trajectories and therapeutic responses Central to this study is evaluating cardiovascular support using the Vasoactive-Inotropic Score VIS and Total Inotrope Exposure TIE Score This study explores the relationship between the etiology of brain death and the pharmacologic cardiovascular support administered as quantified by VIS and TIES scores This study seeks to enhance the management strategies and improve outcomes for patients diagnosed with brain death
Detailed Description:
This study undertakes a comprehensive retrospective analysis of patients admitted to the intensive care unit ICU with an initial diagnosis of brain injury who subsequently progressed to brain death The investigation will meticulously assess these patients demographic profiles pharmacological interventions laboratory parameters and radiological imaging findings The overarching aim is to delineate the clinical trajectory and therapeutic responses of patients diagnosed with brain death critically evaluating the complexities encountered during their management and providing evidence-based insights to inform future treatment protocols
Central to this study is the quantitative assessment of hemodynamic stability using the Vasoactive-Inotropic Score VIS and the Total Inotrope Exposure TIE Score The VIS will quantify the need for vasopressor and inotropic support reflecting the severity of cardiovascular instability At the same time the TIE Score will measure the cumulative exposure to inotropic agents providing a comprehensive evaluation of the overall cardiovascular burden The primary aim of this study is to explore the relationship between the etiology of brain death and the pharmacologic cardiovascular support administered as quantified by VIS and TIES scores Additionally the study will assess how these pharmacologic interventions differ in patients who have undergone decompressive surgery compared to those who have not
This thesis aspires to make a significant contribution to the optimization of management strategies for patients diagnosed with brain death aiming to enhance clinical decision-making and improve patient outcomes in this critically ill cohort
Central to this study is the quantitative assessment of hemodynamic stability using the Vasoactive-Inotropic Score VIS and the Total Inotrope Exposure TIE Score The VIS will quantify the need for vasopressor and inotropic support reflecting the severity of cardiovascular instability At the same time the TIE Score will measure the cumulative exposure to inotropic agents providing a comprehensive evaluation of the overall cardiovascular burden The primary aim of this study is to explore the relationship between the etiology of brain death and the pharmacologic cardiovascular support administered as quantified by VIS and TIES scores Additionally the study will assess how these pharmacologic interventions differ in patients who have undergone decompressive surgery compared to those who have not
This thesis aspires to make a significant contribution to the optimization of management strategies for patients diagnosed with brain death aiming to enhance clinical decision-making and improve patient outcomes in this critically ill cohort
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None