Ignite Creation Date:
2024-10-26 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 3:38 PM
Study NCT ID:
NCT06572059
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-22
Brief Title:
Upper Extremity Motor Imagery Functional Skills and Quality of Life in Patients With Multiple Sclerosis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Relationship Between Upper Extremity Motor Imagery Ability Upper Extremity Functional Skills and Quality of Life in Patients With Multiple Sclerosis
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MotorImagery
Brief Summary:
Multiple sclerosis MS is a chronic inflammatory and autoimmune disease of the central nervous system CNS characterised by axonal loss and demyelination MS is characterized by myelin oligodendrocyte and axon damage MS progresses in a wide spectrum with motor sensory autonomic and cognitive disorders depending on the area affected
Upper extremity dysfunction is common in patients with MS pwMS too 75 of pwMS have impaired ability to perform activities of daily living ADL and quality of life QoL
Motor imagery MI refers to the mental simulation of an action without physical intervention
MS is also characterised by motor and cognitive symptoms Cognitive impairment seen in approximately 40-70 of patients is mainly related to problems in attention information processing speed memory cognitive and visual structure MI refers to the mental simulation of an action without physical intervention which can be classified as explicit or implicit MI skill is linked to motor planning and execution skills MI is related to the subconscious activation of motor systems that play a role not only in producing movement but also in imagining actions learning through observation recognising tools and also understanding other peoples behaviourThe speed and quality of upper extremity functional skills in pwMS may be related to MI ability
Health-related quality of life HRQoL is an individuals assessment of how a health problem and its treatment affect their ability to perform daily activities and roles Research studies have shown that pwMS report lower QoL scores than healthy controls Losses in upper extremity functional skills may affect the activities of daily living and work life in pwMS leading to a decrease in their QoL When evaluating MI ability in these patients the patients functional skills and cognitive status should also be taken into consideration
It is thought that upper extremity MI skills may be negatively affected by impairments with the cognitive syptoms in pwMS The aim of this study is to investigate the relationship between upper extremity MI ability upper extremity functional skills and QoL in pwMS
Upper extremity dysfunction is common in patients with MS pwMS too 75 of pwMS have impaired ability to perform activities of daily living ADL and quality of life QoL
Motor imagery MI refers to the mental simulation of an action without physical intervention
MS is also characterised by motor and cognitive symptoms Cognitive impairment seen in approximately 40-70 of patients is mainly related to problems in attention information processing speed memory cognitive and visual structure MI refers to the mental simulation of an action without physical intervention which can be classified as explicit or implicit MI skill is linked to motor planning and execution skills MI is related to the subconscious activation of motor systems that play a role not only in producing movement but also in imagining actions learning through observation recognising tools and also understanding other peoples behaviourThe speed and quality of upper extremity functional skills in pwMS may be related to MI ability
Health-related quality of life HRQoL is an individuals assessment of how a health problem and its treatment affect their ability to perform daily activities and roles Research studies have shown that pwMS report lower QoL scores than healthy controls Losses in upper extremity functional skills may affect the activities of daily living and work life in pwMS leading to a decrease in their QoL When evaluating MI ability in these patients the patients functional skills and cognitive status should also be taken into consideration
It is thought that upper extremity MI skills may be negatively affected by impairments with the cognitive syptoms in pwMS The aim of this study is to investigate the relationship between upper extremity MI ability upper extremity functional skills and QoL in pwMS
Detailed Description:
Multiple Sclerosis MS a chronic inflammatory disease of the central nervous system CNS is characterized by myelin oligodendrocyte and axon damageMS is a chronic disease with unpredictable clinical presentations ranging from mild infrequent relapses causing mild functional impairment to severe disability including loss of independent walking or severe cognitive impairmentUpper limb dysfunction is common in patients with MS pwMS 75 of pwMS report difficulties performing bimanual tasks that affect their independence and ability to perform daily activities and quality of life QoL Such dysfunction is typically a combination of sensory motor and central deficits that occur proximally distally or throughout both upper limbs and may occur unilaterally or bilaterallyUpper extremity disability in pwMS can be found in the proximal or distal parts of the upper extremity Distal upper extremity dysfunction is often referred to as impaired manual dexterity or hand dysfunction Impaired sensory function fatigue loss of manual skills and mobility are the most commonly reported symptoms in the first year of the disease in pwMS It has also been reported that 75 of the population with MS at the level 65 according to the Expanded Disability Status Scale EDSS has impaired bimanual skills
Motor imagery MI refers to the mental simulation of an action without physical intervention which can be classified as explicit or implicit Expilicit MI is defined as consciously imagining an action This ability is assessed with Mental Chronometer MK and MI questionnaires In implicit MI some tests such as mental rotation MR are applied to ensure that individuals can use their ability unconsciously MI skills are related to motor planning and execution skillsMI supports motor learning and motor performance and is a useful strategy for neurorehabilitation The mechanism of this imagery involves activating the same sensorimotor regions in the brain that are active during the physical completion of the movement thus potentially strengthening and increasing synaptic connectivity for the regions involved in the movement Areas involved in this activation include the primary motor cortex basal ganglia cerebellum premotor cortex supplementary motor area parietal cortex and prefrontal cortex The corticospinal tract is activated during MI an important indication that the imagery stimulates surrounding motor neurons and affects the cortex These neural networks are activated during MI strengthening connections and improving performance during the physical completion of given tasksBecause training in MI is relatively easy and effective in improving motor performance it has recently been used to improve motor deficits in stroke and Parkinsons disease Due to the severe motor impairments in pwMS and the negative effects of these impairments on QoL it has recently been recommended for therapeutic use in MS A study found that patients with MS had significant differences in the mean accuracy and temporal organization of MI ability compared to age-matched healthy controls
MI skills are associated with motor planning and regulationStudies have shown that cognitive performance measured by processing speed and executive function is significantly related to patients motor function In one study the MI ability of pwMS differed significantly in the mean accuracy and temporal organization of MI compared to the MI ability of age-matched healthy controls
Health-related QoL is an individuals assessment of how a health problem and its treatment affect the ability to perform daily life activities and roles Studies have shown that pwMS report lower QoL than healthy controls or those with other chronic diseases such as rheumatoid arthritis and inflammatory bowel disease
There is no study evaluating upper extremity MI skills in pwMS and examining its effects on upper extremity functional skills and QoL In this direction the aim of this study is to investigate the relationship between upper extremity MI ability and upper extremity functional skills and QoL in MS patients
Motor imagery MI refers to the mental simulation of an action without physical intervention which can be classified as explicit or implicit Expilicit MI is defined as consciously imagining an action This ability is assessed with Mental Chronometer MK and MI questionnaires In implicit MI some tests such as mental rotation MR are applied to ensure that individuals can use their ability unconsciously MI skills are related to motor planning and execution skillsMI supports motor learning and motor performance and is a useful strategy for neurorehabilitation The mechanism of this imagery involves activating the same sensorimotor regions in the brain that are active during the physical completion of the movement thus potentially strengthening and increasing synaptic connectivity for the regions involved in the movement Areas involved in this activation include the primary motor cortex basal ganglia cerebellum premotor cortex supplementary motor area parietal cortex and prefrontal cortex The corticospinal tract is activated during MI an important indication that the imagery stimulates surrounding motor neurons and affects the cortex These neural networks are activated during MI strengthening connections and improving performance during the physical completion of given tasksBecause training in MI is relatively easy and effective in improving motor performance it has recently been used to improve motor deficits in stroke and Parkinsons disease Due to the severe motor impairments in pwMS and the negative effects of these impairments on QoL it has recently been recommended for therapeutic use in MS A study found that patients with MS had significant differences in the mean accuracy and temporal organization of MI ability compared to age-matched healthy controls
MI skills are associated with motor planning and regulationStudies have shown that cognitive performance measured by processing speed and executive function is significantly related to patients motor function In one study the MI ability of pwMS differed significantly in the mean accuracy and temporal organization of MI compared to the MI ability of age-matched healthy controls
Health-related QoL is an individuals assessment of how a health problem and its treatment affect the ability to perform daily life activities and roles Studies have shown that pwMS report lower QoL than healthy controls or those with other chronic diseases such as rheumatoid arthritis and inflammatory bowel disease
There is no study evaluating upper extremity MI skills in pwMS and examining its effects on upper extremity functional skills and QoL In this direction the aim of this study is to investigate the relationship between upper extremity MI ability and upper extremity functional skills and QoL in MS patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None